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Urinary Procoagulant Excretion and its Relation to Kidney Function
Abstract
A powerful procoagulant is normally excreted in large amounts in the urine of man, rats and rabbits. The secretion is not altered in a variety of diseases including hemorrhagic diathesis and thromboembolism. In parenchymatous kidney diseases, however, there is a marked reduction of procoagulant excretion. The procoagulant excretion is negatively correlated with BUN, blood creatinine and degree of proteinuria. With marked proteinuria in human or experimental renal disease, the procoagulant content per ml urine and the 24 h excretion drop to very low or zero values. In man, complete recovery of procoagulant excretion is obtained after homotransplantation of a well functioning kidney.
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179818 Nephron 1970;7:165–177Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.