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      Diazoxide treatment for insulinoma: a national UK survey.

      Postgraduate Medical Journal
      Adult, Aged, Aged, 80 and over, Antihypertensive Agents, adverse effects, therapeutic use, Diazoxide, Female, Health Care Surveys, Humans, Insulinoma, drug therapy, secondary, Kidney Diseases, etiology, Male, Middle Aged, Neoplasms, Unknown Primary

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          A survey of UK patients receiving the drug diazoxide, revealed 40 patients with insulinoma on this treatment. Mean age (+/- SD) was 67 +/- 18 years, and 74% were female. Duration of treatment was 7 +/- 6 years (range 1-22). Most (55%) patients were treated with diazoxide because of tumour non-localisation (including failed previous surgery). Metastatic disease (20%) and poor surgical risk (10%) were other indications. Side-effects (notably fluid retention and hirsutism) were common (47%) but not troublesome. Treatment was highly effective--59% were symptom free and 38% had only occasional symptoms. Only one patient had frequent hypoglycaemia despite treatment. We conclude that diazoxide is effective in the management of insulinoma. Side-effects are common but not problematic. Treatment should be considered for all patients not cured by surgery, or unsuitable for surgical treatment.

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