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      The 14-3-3 proteins: integrators of diverse signaling cues that impact cell fate and cancer development

      Trends in Cell Biology
      Elsevier BV

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          Abstract

          The highly conserved 14-3-3 protein family has risen to a position of importance in cell biology owing to its involvement in vital cellular processes, such as metabolism, protein trafficking, signal transduction, apoptosis and cell-cycle regulation. The 14-3-3 proteins are phospho-serine/phospho-threonine binding proteins that interact with a diverse array of binding partners. Because many 14-3-3 interactions are phosphorylation-dependent, 14-3-3 has been tightly integrated into the core phospho-regulatory pathways that are crucial for normal growth and development and that often become dysregulated in human disease states such as cancer. This review examines the recent advances that further elucidate the role of 14-3-3 proteins as integrators of diverse signaling cues that influence cell fate decisions and tumorigenesis.

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          Author and article information

          Journal
          Trends in Cell Biology
          Trends in Cell Biology
          Elsevier BV
          09628924
          January 2009
          January 2009
          : 19
          : 1
          : 16-23
          Article
          10.1016/j.tcb.2008.10.003
          3073487
          19027299
          93a225e3-7e85-4385-937b-a2f2154394f6
          © 2009

          https://www.elsevier.com/tdm/userlicense/1.0/

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