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Abstract
The highly conserved 14-3-3 protein family has risen to a position of importance in
cell biology owing to its involvement in vital cellular processes, such as metabolism,
protein trafficking, signal transduction, apoptosis and cell-cycle regulation. The
14-3-3 proteins are phospho-serine/phospho-threonine binding proteins that interact
with a diverse array of binding partners. Because many 14-3-3 interactions are phosphorylation-dependent,
14-3-3 has been tightly integrated into the core phospho-regulatory pathways that
are crucial for normal growth and development and that often become dysregulated in
human disease states such as cancer. This review examines the recent advances that
further elucidate the role of 14-3-3 proteins as integrators of diverse signaling
cues that influence cell fate decisions and tumorigenesis.