For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
12
views
19
references
 Top references
cited by
11
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      578
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Sublingual Delivery of Vaccines for the Induction of Mucosal Immunity

      review-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The mucosal surfaces are constantly exposed to incoming pathogens which can cause infections that result in severe morbidity and/or mortality. Studies have reported that mucosal immunity is important for providing protection against these pathogens and that mucosal vaccination is effective in preventing local infections. For many years, the sublingual mucosa has been targeted to deliver immunotherapy to treat allergic hypersensitivities. However, the potential of vaccine delivery via sublingual mucosal has received little attention until recently. Recent studies exploring such potential have documented the safety and effectiveness of sublingual immunization, demonstrating the ability of sublingual immunization to induce both systemic and mucosal immune responses against a variety of antigens, including soluble proteins, inter particulate antigens, and live-attenuated viruses.

          This review will summarize the recent findings that address the promising potential of sublingual immunization in proving protection against various mucosal pathogens.

          Related collections

          Most cited references19

          • Record: found
          • Abstract: found
          • Article: not found

          Mucosal immunity: induction, dissemination, and effector functions.

          P Brandtzaeg (2009)
          Prevention of infections by vaccination remains a compelling goal to improve public health. Most infections involve the mucosae, but the development of vaccines against many of these pathogens has yet to be successful. Mucosal vaccines would make immunization procedures easier, be better suited for mass administration, and most efficiently induce immune exclusion - a term coined for non-inflammatory antibody shielding of internal body surfaces - mediated principally by secretory immunoglobulin A (SIgA). The exported antibodies are polymeric, mainly IgA dimers (pIgA) - produced by local plasma cells stimulated by antigens that target the mucosae. SIgA was early shown to be complexed with an epithelial glycoprotein - the secretory component (SC). In 1974, a common SC-dependent transport of pIgA and pentameric IgM was proposed. From the basolateral surface, pIg-SC complexes are taken up by endocytosis and finally extruded into the lumen. Membrane SC is now referred to as polymeric Ig receptor (pIgR). In 1980, it was shown to be synthesized as a larger transmembrane protein - first cloned from rabbit and then from human. Mice deficient for pIgR showed that this is the only receptor responsible for epithelial transport of IgA and IgM. In the gut, induction of B cells occurs in gut-associated lymphoid tissue, particularly the Peyer's patches, but also in mesenteric lymph nodes. Plasma cell differentiation is accomplished in the lamina propria to which the memory/effector cells home. The airways also receive such cells from nasopharynx-associated lymphoid tissue - but by different homing receptors. Such compartmentalization is a challenge for development of mucosal vaccines.
          Article 0 comments Cited 131 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Sublingual immunization induces broad-based systemic and mucosal immune responses in mice.

            Nicolas Çuburu, Mi-Na Kweon, Joo-Hye Song … (2007)
            The potential of sublingual (s.l.) delivery of vaccine was examined in mice. We show the existence of a dense network of dendritic cells (DCs) in the s.l. epithelium and a rapid and transient increase in the frequency of s.l. DCs after topical application of cholera toxin (CT) adjuvant under the tongue. S.l. immunization with ovalbumin and CT induced vigorous systemic and mucosal antibody responses. Such treatment promoted mixed Th1 and Th2 cytokine responses and induced cytotoxic CD8(+) T cells in lung tissues and in systemic lymphoid organs. S.l. immunization was comparable to intranasal immunization and was superior to oral immunization regarding the magnitude and anatomic dissemination of the induced immune responses. S.l. administration of live influenza virus at a dose lethal by the nasal route was well tolerated and did not redirect virus to the olfactory bulb. These features underscore the potential of the s.l. mucosa to serve as an alternative vaccine delivery route.
            Article 0 comments Cited 57 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Sublingual vaccination with influenza virus protects mice against lethal viral infection.

              Cecil Czerkinsky, Taisuke Horimoto, Jong-Youl Ko … (2008)
              We assessed whether the sublingual (s.l.) route would be an effective means of delivering vaccines against influenza virus in mice by using either formalin-inactivated or live influenza A/PR/8 virus (H1N1). Sublingual administration of inactivated influenza virus given on two occasions induced both systemic and mucosal antibody responses and conferred protection against a lethal intranasal (i.n.) challenge with influenza virus. Coadministration of a mucosal adjuvant (mCTA-LTB) enhanced these responses and resulted in complete protection against respiratory viral challenge. In addition, s.l. administration of formalin-inactivated A/PR/8 plus mCTA-LTB induced systemic expansion of IFN-gamma-secreting T cells and virus-specific cytotoxic T lymphocyte responses. Importantly, a single s.l. administration of live A/PR/8 virus was not pathogenic and induced protection mediated by both acquired and innate immunity. Moreover, s.l. administration of live A/PR/8 virus conferred heterosubtypic protection against respiratory challenge with H3N2 virus. Unlike the i.n. route, the A/PR/8 virus, whether live or inactivated, did not migrate to or replicate in the CNS after s.l. administration. Based on these promising findings, we propose that the s.l. mucosal route offers an attractive alternative to mucosal routes for administering influenza vaccines.
              Article 0 comments Cited 53 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Journal
                Journal ID (nlm-ta): Immune Netw
                Journal ID (iso-abbrev): Immune Netw
                Journal ID (publisher-id): IN
                Title: Immune Network
                Publisher: The Korean Association of Immunologists
                ISSN (Print): 1598-2629
                ISSN (Electronic): 2092-6685
                Publication date (Print): June 2013
                Publication date (Electronic): 30 June 2013
                Volume: 13
                Issue: 3
                Pages: 81-85
                Affiliations
                [1 ]Laboratory Science Division, International Vaccine Institute, Seoul 151-919, Korea.
                [2 ]Department of Agricultural Biotechnology and Research Institute for Agriculture and Life Sciences, and the Center for Agricultural Biomaterials, and Center for Food Safety and Toxicology, Seoul National University, Seoul 151-921, Korea.
                Author notes
                Corresponding Author. Man Ki Song, Laboratory Science Division, International Vaccine Institute, SNU Research Park, San 4-8, Nakseongdae-dong, Gwanak-gu, Seoul, Korea. Tel: 82-2-881-1404; Fax: 82-2-881-1410; mksong@ 123456ivi.int

                #These two authors made equal contributions.

                Article
                DOI: 10.4110/in.2013.13.3.81
                PMC ID: 3718922
                PubMed ID: 23885221
                SO-VID: 93a6a735-d792-416c-923b-fcc6708b125a
                Copyright statement: Copyright © 2013 The Korean Association of Immunologists
                License:

                This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 02 May 2013
                Date revision received : 14 May 2013
                Date accepted : 18 May 2013
                Categories
                Subject: Review Article

                ScienceOpen disciplines: Immunology
                Keywords: mucosal immune responses,lung immunity,parenteral immunization,sublingual (s.l.) immunization,vaccine
                Data availability:
                ScienceOpen disciplines: Immunology
                Keywords: mucosal immune responses, lung immunity, parenteral immunization, sublingual (s.l.) immunization, vaccine

                Comments

                Comment on this article

                scite_

                Similar content578

                See all similar

                Cited by10

                See all cited by

                Most referenced authors165

                See all reference authors