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      PD-1: an inhibitory immunoreceptor involved in peripheral tolerance

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      Trends in Immunology
      Elsevier BV

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          Abstract

          PD-1 deficiency causes a variety of autoimmune diseases. Inhibitory signaling through the PD-1 receptor might therefore be involved in the regulation of peripheral tolerance. The constitutive expression of PD-1 ligands (PD-L1 and PD-L2) on parenchymal cells of heart, lung and kidney suggests that the PD-1-PD-L system could provide unique negative signaling to help prevent autoimmune diseases.

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          Author and article information

          Journal
          Trends in Immunology
          Trends in Immunology
          Elsevier BV
          14714906
          May 2001
          May 2001
          : 22
          : 5
          : 265-268
          Article
          10.1016/S1471-4906(01)01888-9
          11323285
          93aeba77-f50c-41fe-98da-d5e34fd89530
          © 2001

          https://www.elsevier.com/tdm/userlicense/1.0/

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