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      Recognition by ELAM-1 of the sialyl-Lex determinant on myeloid and tumor cells.

      Science (New York, N.Y.)
      Amniotic Fluid, chemistry, Antibodies, Monoclonal, pharmacology, Antigens, CD15, metabolism, Carbohydrate Sequence, Cell Adhesion, physiology, Cell Adhesion Molecules, immunology, Cell Membrane, E-Selectin, Endothelium, Vascular, Fucose, Fucosyltransferases, Granulocytes, Immunosorbent Techniques, Interleukin-1, Interleukin-8, Molecular Sequence Data, Neoplasms, Neuraminidase, Oligosaccharides, Orosomucoid, Tumor Cells, Cultured

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          Abstract

          Endothelial leukocyte adhesion molecule-1 (ELAM-1) is an endothelial cell adhesion molecule that allows myeloid cells to attach to the walls of blood vessels adjacent to sites of inflammation. ELAM-1 recognizes the sialyl-Lewis X (sialyl-Lex) determinant, NeuAc alpha 2-3Gal beta 1-4(Fuc alpha 1-3)GlcNAc-, a granulocyte carbohydrate also found on the surface of some tumor cell lines. Binding of myeloid cells to soluble ELAM-1 is inhibited by a monoclonal antibody recognizing sialyl-Lex or by proteins bearing sialyl-Lex, some of which may participate in humoral regulation of myeloid cell adhesion. Stimulated granulocytes also release an inhibitor of ELAM-1 binding that can be selectively adsorbed by monoclonal antibody to sialyl-Lex.

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