5
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Selective neuronal vulnerability of human hippocampal CA1 neurons: lesion evolution, temporal course, and pattern of hippocampal damage in diffusion-weighted MR imaging

      research-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The CA1 (cornu ammonis) region of hippocampus is selectively vulnerable to a variety of metabolic and cytotoxic insults, which is mirrored in a delayed neuronal death of CA1 neurons. The basis and mechanisms of this regional susceptibility of CA1 neurons are poorly understood, and the correlates in human diseases affecting the hippocampus are not clear. Adopting a translational approach, the lesion evolution, temporal course, pattern of diffusion changes, and damage in hippocampal CA1 in acute neurologic disorders were studied using high-resolution magnetic resonance imaging. In patients with hippocampal ischemia ( n=50), limbic encephalitis ( n=30), after status epilepticus ( n=17), and transient global amnesia ( n=53), the CA1 region was selectively affected compared with other CA regions of the hippocampus. CA1 neurons exhibited a maximum decrease of apparent diffusion coefficient (ADC) 48 to 72 hours after the insult, irrespective of the nature of the insult. Hypoxic-ischemic insults led to a significant lower ADC suggesting that the ischemic insult results in a stronger impairment of cellular metabolism. The evolution of diffusion changes show that CA1 diffusion lesions mirror the delayed time course of the pathophysiologic cascade typically observed in animal models. Studying the imaging correlates of hippocampal damage in humans provides valuable insight into the pathophysiology and neurobiology of the hippocampus.

          Related collections

          Author and article information

          Journal
          J Cereb Blood Flow Metab
          J. Cereb. Blood Flow Metab
          Journal of Cerebral Blood Flow & Metabolism
          Nature Publishing Group
          0271-678X
          1559-7016
          November 2015
          17 June 2015
          : 35
          : 11
          : 1836-1845
          Affiliations
          [1 ] Department of Neurology, Memory Disorders and Plasticity Group, University Hospital Schleswig-Holstein , Kiel, Germany
          [2 ] Department of Neurology, Charité Universitätsmedizin Berlin , Berlin, Germany
          [3 ] Institute of Neuroradiology, University Hospital Schleswig-Holstein , Kiel, Germany
          Author notes
          [* ] Department of Neurology, Memory Disorders and Plasticity Group, University Hospital Schleswig-Holstein , Schittenhelmstr. 10, Kiel 24105, Germany. E-mail: t.bartsch@ 123456neurologie.uni-kiel.de
          Article
          PMC4635239 PMC4635239 4635239 jcbfm2015137
          10.1038/jcbfm.2015.137
          4635239
          26082014
          93b7b84a-5613-4e20-a5f7-3ebfa559f2ca
          Copyright © 2015 International Society for Cerebral Blood Flow & Metabolism, Inc.
          Categories
          Original Article

          CA1, encephalitis, hippocampus, memory, stroke, vulnerability

          Comments

          Comment on this article