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      Treatment of Experimental Acute Corneal Inflammation with Inhibitors of the Oxidative Metabolism

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          The authors studied the effect of topical 2% 6-aminonicotin-amide and 0.1 % adenosine on an experimental model of acute corneal inflammation. Luminol-enhanced chemiluminescence (LAC), as an indirect measurement of free-radical release, and computer-assisted planimetry of the corneal ulcer and its infiltrate were performed both ex vivo and in vivo on the fifth day following the induction of experimental alkali burn keratitis. The authors proved that both drugs significantly inhibited LAC both ex vivo and in vivo and that such treatments had also a significant beneficial effect on the evolution of the corneal ulcer and its infiltrate. To the best of the authors’ knowledge, this finding had not been previously reported in experimental corneal inflammation and may indicate that treatment with inhibitors of the oxidative metabolism could offer a new approach in the pharmacological modulation of acute corneal inflammation.

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          Author and article information

          Ophthalmic Res
          Ophthalmic Research
          S. Karger AG
          11 December 2009
          : 25
          : 5
          : 331-336
          Division of Ophthalmology, Laboratory of Ocular Inflammation, University of Alicante Medical School, San Vicente del Raspeig, Spain
          267333 Ophthalmic Res 1993;25:331–336
          © 1993 S. Karger AG, Basel

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          Pages: 6
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