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      Simultaneous Estimation of Four Plasma Androgens Before and After Dynamic Tests in Women with Hirsutism: Correlation with Long-Term Therapy

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          Concentrations of testosterone, △<sup>4</sup>-androstenedione, dihydrotestosterone and Δ<sup>5</sup>-androstenediol were measured in 12 patients affected by hirsutism associated with menstrual disorders. Testosterone was elevated in 9 cases, in whom high levels of Δ<sup>4</sup>-androstenedione and dihydrotestosterone were found, and normal in 3 cases, 2 of which presented high values of dihydrotestosterone and one high levels of Δ<sup>5</sup>-androstenediol. In some hirsute females therefore, other androgens, such as dihydrotestosterone and Δ<sup>5</sup>-androstenediol, play a role in the pathogenesis of hirsutism. Dexamethasone and estrogen progestin combinations were administered for dynamic tests, and results in most cases provided useful information in the selection of suitable long-term therapy.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          21 November 2008
          : 7
          : 1
          : 16-27
          Istituto di Patologia Speciale Medica e Metodologia Clinica II, Università di Roma, Roma
          178704 Horm Res 1976;7:16–27
          © 1976 S. Karger AG, Basel

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          Pages: 12


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