+1 Recommend
0 collections
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Oxytocin in metabolic homeostasis: implications for obesity and diabetes management

      Read this article at

          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.


          Oxytocin was once understood solely as a neuropeptide with a central role in social bonding, reproduction, parturition, lactation and appetite regulation. Recent evidence indicates that oxytocin enhances glucose uptake and lipid utilization in adipose tissue and skeletal muscle, suggesting that dysfunction of the oxytocin system could underlie the pathogenesis of insulin resistance and dyslipidaemia. Murine studies revealed that deficiencies in oxytocin signalling and oxytocin receptor expression lead to obesity despite normal food intake, motor activity and increased leptin levels. In addition, plasma oxytocin concentration is notably lower in obese individuals with diabetes, which may suggest an involvement of the oxytocin system in the pathogenesis of cardiometabolic disease. More recently, small scale studies demonstrated that intranasal administration of oxytocin was associated with significant weight loss as well as improvements in insulin sensitivity and pancreatic β‐cell responsivity in human subjects. The multi‐pronged effects of oxytocin signalling on improving peripheral insulin sensitivity, pancreatic function and lipid homeostasis strongly suggest a role for this system as a therapeutic target in obesity and diabetes management. The complexity of obesity aetiology and the pathogenesis of obesity‐related metabolic complications underscore the need for a systems approach to better understand the role of oxytocin in metabolic function.

          Related collections

          Most cited references 189

          • Record: found
          • Abstract: not found
          • Article: not found


           M Rodbell (1964)
            • Record: found
            • Abstract: found
            • Article: found
            Is Open Access

            Elevated cerebrospinal fluid and blood concentrations of oxytocin following its intranasal administration in humans

            There has been an unprecedented interest in the modulatory effects of intranasal oxytocin on human social cognition and behaviour, however as yet no study has actually demonstrated that this modality of administration increases concentrations of the peptide in the brain as well as blood in humans. Here using combined blood and cerebrospinal fluid (CSF) sampling in subjects receiving either 24 IU of oxytocin (n = 11) or placebo (n = 4) we have shown that oxytocin levels significantly increased in both plasma and CSF. However, whereas oxytocin plasma concentrations peaked at 15 min after intranasal administration and decreased after 75 min, CSF concentrations took up to 75 min to reach a significant level. Moreover, there was no correlation (r = <0.10) between oxytocin plasma and CSF concentrations. Together, these data provide crucial insights into the plasma and CSF kinetics of intranasally administered oxytocin.
              • Record: found
              • Abstract: found
              • Article: not found

              Effects of intranasal oxytocin on emotional face processing in women.

              The neuropeptide oxytocin (OXT) has previously been found to reduce amygdala reactivity to social and emotional stimuli in healthy men. The present study aimed to investigate the effect of intranasally administered OXT on brain activity in response to social emotional stimuli of varying valence in women. In a functional magnetic-resonance imaging study, sixteen women were presented with fearful, angry, happy and neutral facial expressions after a single dose of 24IU OXT or a placebo administration in a within-subject design. Group analysis revealed that the blood-oxygen-level-dependent (BOLD) signal was enhanced in the left amygdala, the fusiform gyrus and the superior temporal gyrus in response to fearful faces and in the inferior frontal gyrus in response to angry and happy faces following OXT treatment. This effect was independent of fixation pattern to specific sections of the facial stimuli as revealed by eye tracking and independent of basal plasma levels of OXT, estradiol, and progesterone. The results are at odds with the previously reported effects found in men. Future studies should include both sexes to determine a possible sexual dimorphism in the neural effects of OXT, considering gonadal steroids and OXT receptor affinity.

                Author and article information

                Obes Rev
                Obes Rev
                Obesity Reviews
                John Wiley and Sons Inc. (Hoboken )
                25 September 2018
                January 2019
                : 20
                : 1 ( doiID: 10.1111/obr.v20.1 )
                : 22-40
                [ 1 ] Clinical Nutrition Research Centre (CNRC), Singapore Institute for Clinical Sciences (SICS), Agency for Science Technology and Research (A*STAR) and National University Health System Singapore
                [ 2 ] Department of Endocrinology Tan Tock Seng Hospital Singapore
                [ 3 ] Cardiovascular and Metabolic Disorders Program Duke‐NUS Medical School Singapore
                [ 4 ] Department of Physiology, Yong Loo Lin School of Medicine National University of Singapore (NUS) Singapore
                [ 5 ] Lee Kong Chian School of Medicine Nanyang Technological University Singapore
                Author notes
                [* ] *Address for correspondence: F Magkos, PhD, Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore. Mailing address: Brenner Centre for Molecular Medicine, 30 Medical Drive, 117609 Singapore.

                E‐mail: fmagkos@ 123456gmail.com

                OBR12757 OBR-05-18-3439.R3
                © 2018 The Authors. Obesity Reviews published by John Wiley & Sons Ltd on behalf of World Obesity Federation

                This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

                Page count
                Figures: 1, Tables: 3, Pages: 19, Words: 8972
                Funded by: Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR)
                Award ID: BMSI/16‐07803C‐R20H
                Obesity‐Diabetes Management/Etiology and Pathophysiology
                Obesity‐Diabetes Management/Etiology and Pathophysiology
                Custom metadata
                January 2019
                Converter:WILEY_ML3GV2_TO_JATSPMC version:5.9.7 mode:remove_FC converted:17.02.2021


                beta cell function, glucose metabolism, insulin sensitivity, lipid metabolism


                Comment on this article