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      Neuromyocysticercosis Causing Lateral Rectus Palsy

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          Abstract

          A 32-year-old nonvegetarian man from a known cysticercosis-endemic region of north India presented with blurriness on looking to the right. Covering one eye restored normal vision. Visual acuity and color vision were normal. He had had two generalized seizures in the previous 2 years for which he had not sought treatment. On examination, he could not abduct the right eye, considered to be a right lateral rectus palsy but no other neurological deficit was apparent. Fundus examination was normal. Cranial magnetic resonance imaging (MRI) showed two well-defined lesions in the brain parenchyma representing degenerating cysts with surrounding inflammation. A cystic lesion was visualized in the right lateral rectus muscle. A diagnosis of neuromyocysticercosis was established (Figure 1A–C Figure 1. (A) T2W cranial magnetic resonance imaging (MRI) showing cystic lesion in the right lateral rectus with an eccentric scolex. (B) Contrast-enhanced cranial MRI showing minimal patchy enhancement of the lesion the right lateral rectus. (C) T2W cranial MRI showing multiple cysts with scolices and perilesional edema at high frontal brain parenchyma. ). Serum immunoglobulin (IgG) cysticercal antibodies (enzyme-linked immunosorbent assay) were positive (> 1/800). He was treated with tapering prednisone and albendazole (400 mg bid × 14 days).1 Carbamazepine, initiated for seizures, and prednisone were tapered off in 1 month.1 Diplopia disappeared 3 months after treatment was initiated, and there was no further seizure. This case depicts that extraocular muscle abnormality can manifest as visual alteration in patients with a history of seizures in cysticercosis-endemic regions.1

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          Clinical symptoms, diagnosis, and treatment of neurocysticercosis.

          The infection of the nervous system by the cystic larvae of Taenia solium (neurocysticercosis) is a frequent cause of seizure disorders. Neurocysticercosis is endemic or presumed to be endemic in many low-income countries. The lifecycle of the worm and the clinical manifestations of neurocysticercosis are well established, and CT and MRI have substantially improved knowledge of the disease course. Improvements in immunodiagnosis have further advanced comprehension of the pathophysiology of this disease. This knowledge has led to individualised treatment approaches that account for the involvement of parenchymal or extraparenchymal spaces, the number and form of parasites, and the extent of degeneration and associated inflammation. Clinical investigations are focused on development of effective treatments and reduction of side-effects induced by treatment, such as seizures, hydrocephalus, infarcts, and neuroinjury.
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            Author and article information

            Journal
            Am J Trop Med Hyg
            Am. J. Trop. Med. Hyg
            tpmd
            The American Journal of Tropical Medicine and Hygiene
            The American Society of Tropical Medicine and Hygiene
            0002-9637
            1476-1645
            07 October 2015
            07 October 2015
            : 93
            : 4
            : 677
            Affiliations
            Department of Neurology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India; Department of Radiology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
            Author notes
            *Address correspondence to Vivek Lal, Department of Neurology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India, 160012. E-mail: vivekl44@ 123456yahoo.com
            Article
            10.4269/ajtmh.15-0068
            4596580
            26446618
            93ff082f-013a-4423-8b7a-2c24756d6913
            ©The American Society of Tropical Medicine and Hygiene

            This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

            History
            : 25 January 2015
            : 20 April 2015
            Categories
            Images in Clinical Tropical Medicine

            Infectious disease & Microbiology
            Infectious disease & Microbiology

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