Blog
About

0
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found

      Relaxation within the Left Ventricular Myocardial Wall

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          To evaluate relaxation mechanics in the wall of the left ventricle needle mounted miniature pressure transducers were inserted at the subendocardial (ENDO) and subepicardial (EPI) level of the anterior wall of the left ventricle during acute open-chest experiments in 10 mongrel dogs. Pressures were recorded during control, volume load and after verapamil administration. The relaxation time constant (τ) was determined by fitting a monoexponential with offset to the isovolumic relaxation period of the ENDO, EPI and left ventricular pressure (LVP) tracings: p = p₀e<sup>-t/τ</sup> + p<sub>1</sub>. Mean τ-values for LVP, ENDO and EPI during control were (mean ± 1 SD, ms): 38 ± 5, 60 ± 12, 83 ± 5; during volume overload: 55 ± 10, 72 ± 20, 85 ± 31 and after verapamil administration: 58 ± 13, 60 ± 17 and 73 ± 15, respectively. Relaxation time constants of ENDO and EPI were significantly longer than those of LVP during control and volume loading but not after verapamil when only EPI was significantly different from LVP. These results demonstrate that relaxation indices obtained from LVP may not always reflect intramyocardial mechanics.

          Related collections

          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1994
          1994
          18 November 2008
          : 85
          : 3-4
          : 175-183
          Affiliations
          UZ Gasthuisberg, KU, Leuven, Belgium
          Article
          176673 Cardiology 1994;85:175–183
          10.1159/000176673
          7987873
          © 1994 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 9
          Categories
          General Cardiology, Basic Research

          Comments

          Comment on this article