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      Risk of recurrent venous thromboembolism in COPD patients: results from a prospective cohort study.

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          Abstract

          We aimed to assess the risk of recurrent venous thromboembolism (VTE) in patients with chronic obstructive pulmonary disease (COPD) following cessation of anticoagulation therapy.In a prospective cohort of 1468 patients with a documented episode of VTE, followed for up to 5 years after cessation of anticoagulation therapy, the diagnosis of COPD was confirmed in 136. The main outcome was recurrent VTE. The secondary outcome was overall mortality. Univariate and multivariate analyses were performed to identify the risk factors of recurrence.Of the 1468 patients included, recurrent VTE was observed in 306 (34 with COPD and 272 without) during a median follow-up period of 36.5 months. The incidence rate of recurrent VTE was 9.1% (95% CI 6.5-12.8) for COPD patients and 7.0% (95% CI 6.2-7.9) for non-COPD patients. COPD was not associated with an increased risk of VTE recurrence on univariate or multivariate analyses (hazard ratio: 1.0 (95% CI 0.7-1.4)). The risk of death, adjusted for demographic and clinical characteristics, showed no increase in COPD patients, as compared to non-COPD patients.In patients with COPD who had an acute episode of VTE, the risk of recurrent VTE was not any higher than that in non-COPD patients.

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          Author and article information

          Journal
          Eur Respir J
          The European respiratory journal
          European Respiratory Society (ERS)
          1399-3003
          0903-1936
          July 2017
          : 50
          : 1
          Affiliations
          [1 ] Dept de Médecine Interne et Pneumologie, Hôpital La Cavale Blanche, Brest, France.
          [2 ] EA3878, Groupe d'Etude de la Thrombose de Bretagne Occidentale (GETBO), Université Européenne de Bretagne, Brest, France.
          [3 ] Centre d'Investigation Clinique CIC-ISERM1412, Hôpital La Cavale Blanche, Brest, France.
          [4 ] Dept de Médecine Interne et Pneumologie, Hôpital La Cavale Blanche, Brest, France francis.couturaud@chu-brest.fr.
          Article
          50/1/1700094
          10.1183/13993003.00094-2017
          28751412
          941f48a1-cbfc-46fd-b6ce-9d103019e8f5
          Copyright ©ERS 2017.

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