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Synthesis and biological evaluation of new heterocyclic quinolinones as anti-parasite and anti-HIV drug candidates
Albert Darque ,
Aurélien Dumètre ,
Sébastien Hutter ,
Gilles Casano ,
Maxime Robin ,
Christophe Pannecouque ,
Nadine Azas
October 2009
October 2009
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Abstract
We have synthesized quinolinones with potential antiparasitic and anti-HIV activities
by an original two-step method involving microwave irradiation and have evaluated
their activities against Plasmodium falciparum, Leishmania donovani, Trichomonas vaginalis,
and HIV. None of the tested compounds had been previously described using this method
of synthesis. One of the compounds had interesting antiparasitic and anti-HIV activity,
which could be improved by substitution with different radicals.