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      Diagnostic Value of OPNI in Hepatocellular Carcinoma

      research-article
      * ,
      Oncology
      S. Karger AG
      Hepatocellular carcinoma, Onodera’s prognostic nutritional index, Diagnosis

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          Abstract

          Introduction: Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in the world. The overall prognosis of patients with HCC is not very ideal. Early detection of HCC has become one of the important means to reduce mortality. More and more studies have pointed out that inflammatory markers based on hematology, such as Onodera’s prognostic nutritional index (OPNI), have important clinical significance. However, there is a lack of relevant research on the diagnosis of HCC by inflammatory markers. Methods: We retrospectively enrolled 633 patients and prospectively recruited 121 consecutive patients, to explore the correlation between inflammatory markers and diagnosis of HCC. Based on the prognostic indicators, different diagnostic models were constructed and the diagnostic performance of different models was further compared. Results: The best cutoff value of OPNI in the diagnosis of HCC is 43.925. Area under the receiver operating characteristics curve (AUC) of gender + age + AFP + OPNI diagnosis of HCC is 0.837 (95% CI: 0.702–0.868) in the retrospective cohort. Compared with gender + age + AFP, the Nagelkerke R<sup>2</sup> of gender + age + AFP + OPNI increased from 0.234 to 0.426, and AUC increased by 0.0973 (95% CI: 0.0659–0.1290). DeLong test, net reclassification improvement (NRI) test, and integrated discrimination improvement (IDI) test are all statistically significant. In the prospective cohort, AUC of gender + age + AFP + OPNI diagnosis of HCC is 0.782 (95% CI: 0.696–0.869). Compared with gender + age + AFP, NRI test is statistically significant (categorical 0.0909 [95% CI: 0.0060–0.1759], p = 0.0359). Conclusion: In the process of monitoring the occurrence of HCC in patients with risk factors, OPNI can be included as appropriate to improve the accuracy of HCC diagnosis.

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          Author and article information

          Journal
          OCL
          Oncology
          10.1159/issn.0030-2414
          Oncology
          Oncology
          S. Karger AG
          0030-2414
          1423-0232
          2023
          August 2023
          14 July 2023
          : 101
          : 8
          : 481-490
          Affiliations
          Department of Infectious Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
          Author notes
          *Daofeng Yang, yangdaofeng@aliyun.com
          Article
          530319 Oncology 2023;101:481–490
          10.1159/000530319
          37454651
          94389fe4-b5d2-4b9f-bc66-eb5bdc84bc41
          © 2023 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.

          History
          : 19 October 2022
          : 09 March 2023
          Page count
          Figures: 5, Tables: 5, Pages: 10
          Funding
          This research received no external funding.
          Categories
          Clinical Study

          Medicine
          Hepatocellular carcinoma,Diagnosis,Onodera’s prognostic nutritional index
          Medicine
          Hepatocellular carcinoma, Diagnosis, Onodera’s prognostic nutritional index

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