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      Evaluation of Surrogate Disk Tests for Detection of Ciprofloxacin and Levofloxacin Resistance in Clinical Isolates of Salmonella enterica.

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          Abstract

          Detection of fluoroquinolone resistance in Salmonella enterica has become increasingly difficult due to evolving resistance mechanisms to this antimicrobial class in this organism. We evaluated two quinolone disks and five fluoroquinolone disks for their ability to act as a surrogate agent for the detection of fluoroquinolone resistance in a collection of 136 S. enterica isolates, including 111 with intermediate or resistant ciprofloxacin MICs mediated by a variety of resistance mechanisms. Ciprofloxacin, ofloxacin, and pefloxacin disks detected all isolates resistant to ciprofloxacin (0% very major error) and yielded false resistance (major error) in 8, 4, and 12% of susceptible isolates, respectively. Ciprofloxacin and pefloxacin provided clearer differentiation of susceptible and resistant isolates.

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          Author and article information

          Journal
          J. Clin. Microbiol.
          Journal of clinical microbiology
          American Society for Microbiology
          1098-660X
          0095-1137
          Nov 2015
          : 53
          : 11
          Affiliations
          [1 ] Pathology and Laboratory Medicine, University of California, Los Angeles, California, USA Santa Clara Valley Medical Center, Santa Clara, California, USA.
          [2 ] Statens Serum Institut, Copenhagen, Denmark.
          [3 ] Pathology and Laboratory Medicine, University of California, Los Angeles, California, USA.
          [4 ] Pathology and Laboratory Medicine, University of California, Los Angeles, California, USA rhumphries@mednet.ucla.edu.
          Article
          JCM.01393-15
          10.1128/JCM.01393-15
          4609702
          26292293

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