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      FORMULATION AND EVALUATION OF ENTERIC COATED TABLETS OF PROTON PUMP INHIBITOR

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          Abstract

          The present study was an attempt to formulate and evaluate enteric coated tablets for esomeprazole magnesium trihydrate. Different core tablets were prepared and formulation (F-1) was selected for further enteric coating, based on the disintegration time. Seal coating was applied to achieve 3% weight gain using opadry®. Enteric coating was carried out using different polymers like Eudragit L-30 D-55, hydroxy propyl methylcellulose phthalate, cellulose acetate phthalate and Acryl-EZE® to achieve 5% weight gain. Disintegration studies showed that the formulations failed in 0.1 N HCl media. Hence the quantity of enteric coating was increased to 8% w/w. In vitro analysis of the developed tablets was carried out. Results from disintegration time and dissolution rate studies indicate that all the esomeprazole enteric tablets prepared possess good integrity, desirable for enteric coated tablets. Among the polymers studied, the methacrylic polymers exhibited better dissolution rate than the cellulose polymers. Stability studies indicate that the prepared formulations were stable for a period of three months. This study concluded that enteric coated tablets of esomeprazole can be prepared using any of the enteric coating polymer studied using a minimal weight gain of 8%.

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          Author and article information

          Journal
          J Basic Clin Pharm
          J Basic Clin Pharm
          JBCP
          Journal of Basic and Clinical Pharmacy
          Medknow Publications & Media Pvt Ltd (India )
          0976-0105
          0976-0113
          September 2010-November 2010
          15 November 2010
          : 1
          : 4
          : 215-221
          Affiliations
          [1 ]M.M. College of Pharmacy, M.M. University, Mullana, Ambala, India
          [2 ]PES College of Pharmacy, Bangalore, Karnataka, India
          [3 ]Faculty of Pharmacy, Al-Mergeb University, Al-Khoms, Libya
          [4 ]College Of Clinical Pharmacy, King Faisal University, Al-Ahsa, Saudi Arabia
          Author notes
          [* ]Corresponding Author: E-mail: banroop@ 123456gmail.com
          Article
          JBCP-1-215
          3979213
          Copyright: © Journal of Basic and Clinical Pharmacy

          This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

          Categories
          Original Article

          esomeprazole, enteric coating, tablets, eudragit, hpmcp, cap, stability

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