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      Association between thrombotic microangiopathy and activated alternative complement pathway in malignant nephrosclerosis.

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          Abstract

          Malignant nephrosclerosis, defined as renal microangiopathy in the setting of severe hypertension, remains a critical renal emergency leading to end-stage renal disease despite aggressive anti-hypertensive treatment. Recently, activation of the complement alternative pathway (AP) has been reported to play a prominent role in the pathogenesis of malignant nephrosclerosis. However, subsequent study failed to recapitulate the findings of genetic complement abnormalities in the disease. This study aimed to determine the presence of AP activation and genetic complement defects and establish their correlations to renal microangiopathy lesions, clinical features and prognosis in patients with malignant nephrosclerosis.

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          Author and article information

          Journal
          Nephrol Dial Transplant
          Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
          Oxford University Press (OUP)
          1460-2385
          0931-0509
          Dec 26 2020
          Affiliations
          [1 ] Department of Nephrology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
          [2 ] Renal Path Diagnostics at Pathologists BioMedical Laboratories, Lewisville, TX, USA.
          Article
          6050609
          10.1093/ndt/gfaa280
          33367879
          944f2028-432e-4154-8535-47273aae108d
          © The Author(s) 2020. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.
          History

          alternative pathway,complement,malignant hypertension,malignant nephrosclerosis,thrombotic microangiopathy

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