Tethered capsule endomicroscopy enables less-invasive imaging of gastrointestinal tract microstructure

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Abstract

Here, we introduce “tethered capsule endomicroscopy,” that involves swallowing an optomechanically-engineered pill that captures cross-sectional, 30 μm (lateral) × 7 μm (axial) resolution, microscopic images of the gut wall as it travels through the digestive tract. Results in human subjects show that this technique rapidly provides three-dimensional, microstructural images of the upper gastrointestinal tract in a simple and painless procedure, opening up new opportunities for screening for internal diseases.

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Author and article information

Journal

Journal ID (nlm-journal-id): 9502015

Journal ID (pubmed-jr-id): 8791

Journal ID (nlm-ta): Nat Med

Journal ID (iso-abbrev): Nat. Med.

Title: Nature medicine

ISSN (Print): 1078-8956

ISSN (Electronic): 1546-170X

Publication date Nihms-submitted: 19 September 2012

Publication date (Electronic): 13 January 2013

Publication date (Print): February 2013

Publication date PMC-release: 01 August 2013

Volume: 19

Issue: 2

Pages: 238-240

Affiliations

[1 ]Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA

[2 ]Department of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA

[3 ]Department of Pulmonology, Massachusetts General Hospital and Harvard Medical School, Boston, MA

[4 ]Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA

[5 ]Harvard-MIT Health Sciences and Technology, Cambridge, MA

Author notes

[* ]Correspondence to: Guillermo J. Tearney, MD PhD, Professor of Pathology, Harvard Medical School, Massachusetts General Hospital and Wellman Center for Photomedicine, 40 Blossom St, RSH160, Boston, MA 02114, gtearney@ 123456partners.org ; Phone: (617) 724-2979; Fax: (617) 726-4103

Article

Manuscript ID: NIHMS398265

DOI: 10.1038/nm.3052

PMC ID: 3567218

PubMed ID: 23314056

SO-VID: 9452aa5f-c275-4bdf-882d-1e7a7c23a5a6

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Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms

History

Funding

Funded by: National Institute of Diabetes and Digestive and Kidney Diseases : NIDDK

Award ID: R01 DK091923 || DK

Funded by: National Cancer Institute : NCI

Award ID: R01 CA103769 || CA

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