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      Recent Progress in Organocatalytic Asymmetric Domino Transformations

      1 , 1
      Advanced Synthesis & Catalysis
      Wiley

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          Organocatalytic cascade reactions as a new tool in total synthesis.

          The total synthesis of natural products and biologically active compounds, such as pharmaceuticals and agrochemicals, has reached an extraordinary level of sophistication. We are, however, still far away from the 'ideal synthesis' and the state of the art is still frequently hampered by lengthy protecting-group strategies and costly purification procedures derived from the step-by-step protocols. In recent years several new criteria have been brought forward to solve these problems and to improve total synthesis: atom, step and redox economy or protecting-group-free synthesis. Over the past decade the research area of organocatalysis has rapidly grown to become a third pillar of asymmetric catalysis standing next to metal and biocatalysis, thus paving the way for a new and powerful strategy that can help to address these issues - organocatalytic cascade reactions. In this Review we present the first applications of such asymmetric organocascade reactions to the total synthesis of natural products.
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            Cascade reactions in total synthesis.

            The design and implementation of cascade reactions is a challenging facet of organic chemistry, yet one that can impart striking novelty, elegance, and efficiency to synthetic strategies. The application of cascade reactions to natural products synthesis represents a particularly demanding task, but the results can be both stunning and instructive. This Review highlights selected examples of cascade reactions in total synthesis, with particular emphasis on recent applications therein. The examples discussed herein illustrate the power of these processes in the construction of complex molecules and underscore their future potential in chemical synthesis.
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              Domino Reactions in Organic Synthesis

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                Author and article information

                Journal
                Advanced Synthesis & Catalysis
                Adv. Synth. Catal.
                Wiley
                1615-4150
                1615-4169
                January 04 2018
                November 14 2017
                January 04 2018
                : 360
                : 1
                : 2-79
                Affiliations
                [1 ]Department of Chemistry University of Texas at San Antonio One UTSA Circle San Antonio TX 78249-0698 USA
                Article
                10.1002/adsc.201701059
                945ec9bb-c419-4787-bf62-c947bf3686a2
                © 2018

                http://onlinelibrary.wiley.com/termsAndConditions#am

                http://onlinelibrary.wiley.com/termsAndConditions#vor

                http://doi.wiley.com/10.1002/tdm_license_1.1

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