Three patients, two men aged 27 and 33 years and one woman aged 31 years, developed several opportunistic infections without presence of HIV infection. Patient A died after suffering Candida stomatitis, extrapulmonary Mycobacterium avium infection, cytomegalovirus infection and Aspergillus pneumonia; patient B recovered from a disseminated M. kansasii infection; patient C suffered from verrucae planae. These patients had CD4(+)-T lymphocytopenia, a shortage of helper T cells. Idiopathic CD4(+)-T lymphocytopenia is a heterogeneous pathological condition with normal serum immunoglobulin concentrations. Treatment consists of combating and preventing infections.