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      Development of zein nanoparticles coated with carboxymethyl chitosan for encapsulation and controlled release of vitamin D3.

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          Abstract

          In this study, zein nanoparticles coated with carboxymethyl chitosan (CMCS) were prepared to encapsulate vitamin D3 (VD3). VD3 was first encapsulated into zein nanoparticles using a low-energy phase separation method and coated with CMCS simultaneously. Then, calcium was added to cross-link CMCS to achieve thicker and denser coatings. The nanoparticles with CMCS coatings had a spherical structure with particle size from 86 to 200 nm. The encapsulation efficiency was greatly improved to 87.9% after CMCS coating, compared with 52.2% for that using zein as a single encapsulant. The physicochemical properties were characterized by differential scanning calorimetry and Fourier transform infrared spectroscopy. Nanoparticles with coatings provided better controlled release of VD3 in both PBS medium and simulated gastrointestinal tract. Photostability against UV light was significantly improved after encapsulation. Encapsulation of hydrophobic nutrients in zein nanoparticles with CMCS coatings is a promising approach to enhance chemical stability and controlled release property.

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          Author and article information

          Journal
          J. Agric. Food Chem.
          Journal of agricultural and food chemistry
          American Chemical Society (ACS)
          1520-5118
          0021-8561
          Jan 25 2012
          : 60
          : 3
          Affiliations
          [1 ] Department of Nutrition and Food Science, University of Maryland, College Park, Maryland 20742, United States.
          Article
          10.1021/jf204194z
          22224939
          9476106a-2c93-4a36-ac01-b55b88fc98b7
          History

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