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      Effects of Neomycin on 45Ca Binding and Distribution in Canine Arteries

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          Abstract

          The effects of neomycin (7.0 mM) on 45Ca movements and distribution were investigated in canine aortae and in canine carotid and terminal mesenteric arteries. Uptake of <sup>45</sup>Ca was measured in calcium-free solution; the <sup>45</sup>Ca tissue spaces in the carotid and terminal mesenteric arteries were 2–4 times greater than those observed in the aorta. Exposure of the aortae and the terminal mesenteric arteries to 1.5 mM Ca<sup>++</sup> during the washout elicited large increases in <sup>45</sup>Ca efflux in both preparations (increase in terminal mesenteric > aorta). Moreover, in all three arterial preparations, neomycin reduced <sup>45</sup>Ca uptake and induced a sustained increase in <sup>45</sup>Ca efflux (effects on terminal mesenteric > carotid > aorta). The terminal mesenteric and carotid arteries may accumulate and bind <sup>45</sup>Ca at superficial membrane sites (readily exchangeable <sup>45</sup>Ca) to a greater degree than does the aorta. If Ca<sup>++</sup> located at these membrane sites contributes directly to the maintenance of mechanical responsiveness, then agents which alter membrane binding of Ca<sup>++</sup> (e.g. neomycin) may exert a stronger action on these highly reactive vessels. Thus, contractile responsiveness in peripheral arteries may depend upon depots of superficially bound Ca<sup>++</sup> to a greater degree than in the more centrally located aorta.

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          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          1018-1172
          1423-0135
          1975
          1975
          18 September 2008
          : 12
          : 4
          : 248-260
          Affiliations
          Department of Pharmacology, University of Texas Southwestern Medical School, Dallas, Tex.
          Article
          158060 Blood Vessels 1975;12:248–260
          10.1159/000158060
          © 1975 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 13
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