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      Adenocarcinoma gástrico Borrmann tipo IV: análise dos resultados da ressecção curativa Translated title: Type IV Borrmann gastric adenocarcinoma: analysis of curative resection results

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          Abstract

          OBJETIVO: Avaliar o resultado obtido com a ressecção de intenção curativa do adenocarcinoma gástrico Borrmann IV(B IV), através da análise de variáveis clínicas, cirúrgicas e anatomopatológicas, identificando quais destes fatores prognósticos se associaram à sobrevida. MÉTODOS: Foram analisados retrospectivamente, no período de janeiro de 1997 a dezembro de 2005, 123 pacientes com adenocarcinoma gástrico B IV submetidos ao tratamento cirúrgico no Serviço de Cirurgia Abdômino-Pélvica do Instituto Nacional de Câncer (INCA). O grupo submetido à ressecção curativa teve analisado diversos fatores prognósticos com relação à sobrevida global. RESULTADOS: Dos 123 pacientes estudados, 68 foram submetidos à gastrectomia, 52 (42,3%) com intenção curativa e 16 (13%) como ressecção paliativa, enquanto 55 (44,7%) tiveram doença não passível de ressecção. Três óbitos no pós-operatório seguiram-se à ressecção curativa, configurando uma taxa de mortalidade de 5,76%. Em nove (17,3%) pacientes ocorreram complicações técnicas, sendo a fístula esofagojejunal com sete casos, a mais frequente. Todos os óbitos e complicações técnicas ocorreram após gastrectomias totais, que foi o tipo de ressecção curativa mais realizada nesta série. O padrão de recidiva mais comum foi a carcinomatose peritoneal. A localização do tumor, metástase linfonodal, invasão linfática e estadiamento patológico foram considerados fatores prognósticos significantes. O tempo de sobrevida mediano foi de 29 meses, com taxa de sobrevida em cinco anos de 33% nos pacientes submetidos à ressecção curativa CONCLUSÃO: A ressecção com intenção curativa do adenocarcinoma gástrico B IV apresentou um impacto positivo na sobrevida dos pacientes com a doença nos estágios IB, II e III; com até 15 linfonodos comprometidos (pN2) e no tipo localizado.

          Translated abstract

          OBJECTIVE: To evaluate the results obtained with curative resection of Borrmann IV gastric adenocarcinoma (B IV) through the analysis of clinical, surgical and pathological data, identifying which of these prognostic factors were associated with survival. METHODS: We retrospectively analyzed 123 patients with B IV gastric adenocarcinoma undergoing surgical treatment at the Department of the pelvic-abdominal surgeries of the National Cancer Institute (INCA) from January 1997 to December 2005. The group undergoing curative resection was examined for various prognostic factors regarding overall survival. RESULTS: Of the 123 patients studied, 68 underwent gastrectomy, 52 (42.3%) with curative intent and 16 (13%) palliative resection, while 55 (44.7%) had disease not subject to resection. Three postoperative deaths followed the curative resection, constituting a mortality rate of 5.76%. In nine (17.3%) patients there were technical complications, and esophagojejunal fistula seven cases, the most frequent. All technical complications and deaths occurred after total gastrectomy, which was the most commonly performed curative resection type in this series. The most common pattern of recurrence was peritoneal carcinomatosis. The location of the tumor, lymph node metastasis, lymphatic invasion and pathological staging were considered significant prognostic factors. The median survival time was 29 months, with a rate of five-year survival of 33% in patients undergoing curative resection. CONCLUSION: The curative resection of B IV gastric adenocarcinoma had a positive impact on survival of patients with the disease in stages IB, II and III, with up to 15 lymph nodes (pN2) and localized type.

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          Most cited references28

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          Japanese Classification of Gastric Carcinoma - 2nd English Edition -

          PREFACE: The first edition of the General Rules for Gastric Cancer Study was published by the Japanese Research Society for Gastric Cancer (JRSGC) in 1963. The first English edition [1] was based on the 12th Japanese edition and was published in 1995. In 1997, the JRSGC was transformed into the Japanese Gastric Cancer Association and this new association has maintained its commitment to the concept of the Japanese Classification. This second English edition was based on the 13th Japanese edition [2].The aim of this classification is to provide a common language for the clinical and pathological description of gastric cancer and thereby contribute to continued research and improvements in treatment and diagnosis.
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            Clinicopathological features of patients with Borrmann type IV gastric carcinoma.

            To determine whether there is a specific pattern of clinicopathological features that could be used to distinguish -Borrmann type IV gastric carcinoma from other types of gastric carcinoma. We retrospectively analysed the clinicopathological features of patients with Borrmann type IV carcinoma of the stomach. The results were compared with the features of patients who had other types of gastric carcinoma. The incidence of Borrmann type IV gastric carcinoma was 11.0% (199 patients). A poorly differentiated tumour was found in 120 out of 199 patients (60.3%) with Borrmann type IV gastric carcinoma. The positive lymph node metastasis was found in 150 out of 199 patients (75.4%) with Borrmann type IV gastric carcinoma (P < 0.0001). The incidence of serosal invasion (91.5%) and peritoneal dissemination (37.7%) was significantly higher in these patients. Of the patients with Borrmann type IV gastric carcinoma,161 patients (80.9%) were classified as either stage III or IV at initial diagnosis. The curative resection rate of patients with Borrmann type IV gastric carcinoma was lower than that of patients with other types of gastric carcinoma (P < 0.001). The survival rate was higher in patients with a curative resection(P < 0.001). The 5-year survival rate of patients with Borrmann type IV tumour was lower than that of patients with other types of gastric carcinoma (P < 0.001). The 5-year survival rates were 90.9% for stage I patients with Borrmann type IV gastric carcinoma and 39.5%, 18.6% and 8.7% for stages II, III and IV, respectively (P < 0.001). Improving the prognosis for patients with Borrmann type IV gastric carcinoma requires early detection and a curative resection.
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              Classification of gastric carcinoma.

              F Borchard (1990)
              In this review the main classification systems of gastric carcinomas are described. Besides topographical aspects, the macroscopic features of early and advanced gastric cancers are summarized. Also scanning microscopic typings, the WHO typing, and various histogenetic classifications are reviewed. The main prognostic categorizations, like the TNM classification of the UICC and the Japanese classification of lymph nodes, are described, together with their prognostic significance. Finally, the special significance of the R classification is stressed.
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                Author and article information

                Contributors
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Journal
                rcbc
                Revista do Colégio Brasileiro de Cirurgiões
                Rev. Col. Bras. Cir.
                Colégio Brasileiro de Cirurgiões (Rio de Janeiro )
                1809-4546
                August 2011
                : 38
                : 4
                : 237-244
                Affiliations
                [1 ] Universidade Federal Fluminense Brazil
                [2 ] Universidade Federal do Rio de Janeiro Brazil
                Article
                S0100-69912011000400007
                10.1590/S0100-69912011000400007
                947c36d1-b30a-48aa-9d9e-126a42c607e3

                http://creativecommons.org/licenses/by/4.0/

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                SciELO Brazil

                Self URI (journal page): http://www.scielo.br/scielo.php?script=sci_serial&pid=0100-6991&lng=en
                Categories
                SURGERY

                Surgery
                Stomach neoplasms,surgery,Outcome assessment,Estômago,Prognóstico,Adenocarcinoma,Neoplasias gástricas,cirurgia,Avaliação de resultados,Stomach,Prognosis

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