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      Influence of vagal control on sex-related differences in left ventricular mechanics and hemodynamics

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          Abstract

          Left ventricular (LV) twist mechanics differ between men and women during acute physiological stress, which may be partly mediated by sex differences in autonomic control. While men appear to have greater adrenergic control of LV twist, the potential contribution of vagal modulation to sex differences in LV twist remains unknown. Therefore, the present study examined the role of vagal control on sex differences in LV twist during graded lower body negative pressure (LBNP) and supine cycling. On two separate visits, LV mechanics were assessed using two-dimensional speckle-tracking echocardiography in 18 men (22 ± 2 yr) and 17 women (21 ± 4 yr) during −40- and −60-mmHg LBNP and 25% and 50% of peak supine cycling workload with and without glycopyrrolate (vagal blockade). LV twist was not different at baseline but was greater in women during −60 mmHg in both control (women: 16.0 ± 3.4° and men: 12.9 ± 2.3°, P = 0.004) and glycopyrrolate trials (women: 17.7 ± 5.9° and men: 13.9 ± 3.3°, P < 0.001) due to greater apical rotation during control (women: 11.9 ± 3.6° and men: 7.8 ± 1.5°, P < 0.001) and glycopyrrolate (women: 11.6 ± 4.9° and men: 7.1 ± 3.6°, P = 0.009). These sex differences in LV twist consistently coincided with a greater LV sphericity index (i.e., ellipsoid geometry) in women compared with men. In contrast, LV twist did not differ between the sexes during exercise with or without glycopyrrolate. In conclusion, women have augmented LV twist compared with men during large reductions to preload, even during vagal blockade. As such, differences in vagal control do not appear to contribute to sex differences in the LV twist responses to physiological stress, but they may be related to differences in ventricular geometry.

          NEW & NOTEWORTHY This is the first study to specifically examine the role of vagal autonomic control on sex-related differences in left ventricular (LV) mechanics. Contrary to our hypothesis, vagal control does not appear to primarily determine sex differences in LV mechanical or hemodynamic responses to acute physiological stress. Instead, differences in LV geometry may be a more important contributor to sex differences in LV mechanics.

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          Author and article information

          Journal
          Am J Physiol Heart Circ Physiol
          Am. J. Physiol. Heart Circ. Physiol
          ajpheart
          Am J Physiol Heart Circ Physiol
          AJPHEART
          American Journal of Physiology - Heart and Circulatory Physiology
          American Physiological Society (Bethesda, MD )
          0363-6135
          1522-1539
          1 September 2018
          1 June 2018
          1 September 2019
          : 315
          : 3
          : H687-H698
          Affiliations
          [1] 1Centre for Heart, Lung, and Vascular Health, University of British Columbia , Kelowna, British Columbia, Canada
          [2] 2Cardiff School of Sport, Cardiff Metropolitan University , Cardiff, United Kingdom
          [3] 3School of Medicine, Cardiff University , Cardiff, United Kingdom
          Author notes
          Address for reprint requests and other correspondence: A. M. Williams, Blusson Spinal Cord Centre, 818 W. 10th Ave., Vancouver, BC, Canada V5Z 1M9 (e-mail: alex.williams@ 123456ubc.ca ).
          Article
          PMC6172639 PMC6172639 6172639 H-00733-2017 H-00733-2017
          10.1152/ajpheart.00733.2017
          6172639
          29856652
          948007ec-5665-47d5-b6b7-30d2ee98073c
          Copyright © 2018 the American Physiological Society
          Funding
          Funded by: Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada (NSERC Canadian Network for Research and Innovation in Machining Technology) 10.13039/501100002790
          Award ID: 371950
          Award ID: CGSD2-460367-2014
          Funded by: Michael Smith Foundation for Health Research (MSFHR) 10.13039/501100000245
          Award ID: CGS-MSFSS 477373
          Award ID: Grant 7085
          Categories
          Research Article
          Integrative Cardiovascular Physiology and Pathophysiology

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