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      AB186. Association study between polymorphisms of PRMT6, PEX10, SOX5, and non-obstructive azoospermia in the Han Chinese population

      Translational Andrology and Urology

      AME Publishing Company

      Polymorphisms, PRMT6, PEX10, SOX5, non-obstructive azoospermia

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          Abstract

          A previous genomewide association study of non-obstructive azoospermia (NOA) in the Han Chinese population identified three risk loci (rs12097821, rs2477686, and rs10842262) and provided strong evidence for a genetic influence in male infertility. However, recently, a follow-up study of these single nucleotide polymorphism (SNP) loci in the Japanese population showed that none of them were significantly associated with NOA. Therefore, we conducted an association study, consisting of 550 NOA cases and 555 normal controls, to further validate whether the risk of those three SNPs still existed in an independent Han Chinese male population. The association studies did not support the association of rs12097821 and rs2477686 with NOA for both genotype and allele distributions, but rs10842262 in the SOX5 gene was significantly associated with NOA (chi square =9.31; P=0.0095 and chi square =9.27; P=0.0023, respectively). Our study provides genetic evidence for SOX5 polymorphism in NOA, contributing to predicting males at high risk of NOA in Han Chinese population. Considering genetic differences among populations, future validating studies in independent samples are suggested

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          Author and article information

          Affiliations
          Shanghai Human Sperm Bank Research Laboratory, Shanghai 200001, China
          Journal
          Transl Androl Urol
          Transl Androl Urol
          TAU
          Translational Andrology and Urology
          AME Publishing Company
          2223-4691
          September 2014
          September 2014
          : 3
          : Suppl 1
          4708472 tau-03-S1-AB186 10.3978/j.issn.2223-4683.2014.s186
          2014 Translational Andrology and Urology. All rights reserved.
          Categories
          Abstract Publication Basic Research

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