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      A placebo-controlled, double-blind study of eicosapentaenoic acid-rich fish oil in patients with stable angina pectoris.

      Current medical research and opinion

      Middle Aged, Adult, Male, Humans, drug effects, Hemodynamics, therapeutic use, analysis, Fish Oils, Female, Exercise Test, Erythrocyte Deformability, pharmacology, Eicosapentaenoic Acid, Double-Blind Method, Clinical Trials as Topic, Blood Viscosity, Bleeding Time, physiopathology, diet therapy, blood, Angina Pectoris

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          Abstract

          A study was carried out to evaluate the clinical and haematological effects of dietary supplementation with eicosapentaenoic acid (EPA)-rich fish oil (MaxEPA', 2.8 g EPA daily) compared to placebo (olive oil) in 10 patients with stable angina pectoris. After 3 months, there was a significant increase in red cell deformability (p less than 0.001), reduced whole blood viscosity (p less than 0.02), and prolonged skin bleeding time (p less than 0.001) in the fish oil group compared to the placebo group. Haematocrit, plasma viscosity, fibrinogen concentration, platelet count, and in vitro platelet aggregation were unaltered. No significant symptomatic or objective improvement was noted in angina pectoris in either group despite the significant rheological changes produced in the patients receiving fish oil.

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          Journal
          10.1185/03007999009111485
          2188794

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