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      Sirt1 regulates canonical TGF-β signalling to control fibroblast activation and tissue fibrosis.

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          Abstract

          Sirt1 is a member of the sirtuin family of proteins. Sirt1 is a class III histone deacetylase with important regulatory roles in transcription, cellular differentiation, proliferation and metabolism. As aberrant epigenetic modifications have been linked to the pathogenesis of systemic sclerosis (SSc), we aimed to investigate the role of Sirt1 in fibroblast activation.

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          Author and article information

          Journal
          Ann. Rheum. Dis.
          Annals of the rheumatic diseases
          1468-2060
          0003-4967
          Jan 2016
          : 75
          : 1
          Affiliations
          [1 ] Department of Internal Medicine III, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.
          [2 ] Department of Internal Medicine III, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany Department of Rheumatology, 1st Faculty of Medicine, Institute of Rheumatology, Charles University, Prague, Czech Republic.
          [3 ] Center of Experimental Rheumatology and Zurich Center of Integrative Human Physiology, University Hospital Zurich, Zurich, Switzerland.
          Article
          annrheumdis-2014-205740
          10.1136/annrheumdis-2014-205740
          25180292
          Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

          Fibroblasts, Systemic Sclerosis, Treatment

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