Sirt1 regulates canonical TGF-β signalling to control fibroblast activation and tissue fibrosis.

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Abstract

Sirt1 is a member of the sirtuin family of proteins. Sirt1 is a class III histone deacetylase with important regulatory roles in transcription, cellular differentiation, proliferation and metabolism. As aberrant epigenetic modifications have been linked to the pathogenesis of systemic sclerosis (SSc), we aimed to investigate the role of Sirt1 in fibroblast activation.

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Author and article information

Journal

Journal ID (iso-abbrev): Ann. Rheum. Dis.

Title: Annals of the rheumatic diseases

ISSN (Electronic): 1468-2060

ISSN (Print): 0003-4967

Publication date (Electronic): Jan 2016

Volume: 75

Issue: 1

Affiliations

[1 ] Department of Internal Medicine III, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.

[2 ] Department of Internal Medicine III, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany Department of Rheumatology, 1st Faculty of Medicine, Institute of Rheumatology, Charles University, Prague, Czech Republic.

[3 ] Center of Experimental Rheumatology and Zurich Center of Integrative Human Physiology, University Hospital Zurich, Zurich, Switzerland.

Article

Publisher Item ID: annrheumdis-2014-205740

DOI: 10.1136/annrheumdis-2014-205740

PubMed ID: 25180292

SO-VID: 94a6c9f0-cc1e-499c-8577-af9a89160cd4

Copyright © Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

History

Keywords: Fibroblasts,Systemic Sclerosis,Treatment

Data availability:

Keywords: Fibroblasts, Systemic Sclerosis, Treatment

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