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      Gastrointestinal behavior of nano- and microsized fenofibrate: In vivo evaluation in man and in vitro simulation by assessment of the permeation potential.

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          Abstract

          The purpose of this study was (i) to evaluate the gastrointestinal behavior of micro- and nanosized fenofibrate in humans and (ii) to develop a simple yet qualitatively predictive in vitro setup that simulates the observed absorption-determining factors.

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          Author and article information

          Journal
          Eur J Pharm Sci
          European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
          Elsevier BV
          1879-0720
          0928-0987
          Sep 18 2015
          : 77
          Affiliations
          [1 ] Drug Delivery & Disposition, KU Leuven, Gasthuisberg O&N2, Herestraat 49, Box 921, 3000 Leuven, Belgium.
          [2 ] Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Belgium.
          [3 ] Drug Delivery & Disposition, KU Leuven, Gasthuisberg O&N2, Herestraat 49, Box 921, 3000 Leuven, Belgium. Electronic address: patrick.augustijns@pharm.kuleuven.be.
          Article
          S0928-0987(15)00275-4
          10.1016/j.ejps.2015.05.023
          26004010
          94a79bf5-f8d1-4f24-99da-0203d28c06f7
          History

          Clinical study,Dialysis,Dissolution,Fenofibrate,Microparticles,Nanoparticles,Permeation,Solubility–permeability interplay

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