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      Plasma Thyrotropin Levels in Severe Infantile Malnutrition


      Hormone Research in Paediatrics

      S. Karger AG

      Thyrotropin, Thyroid, Malnutrition, Marasmus, Kwashiorkor

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          The plasma thyrotropin levels were determined in 35 children, aged 5 to 30 months, who were suffering from severe malnutrition due to socioeconomic factors. Plasma thyrotropin hormone was found to be normal in patients with the marasmic-kwashiorkor type of malnutrition (0.20 ± 0.07 mU/ml) and moderately decreased in those with the marasmic type (0.13 ± 0.04 mU/ml), despite the tendency to low levels of protein-bound iodine and thyroxine. Some patients also had abnormal amounts of the hormonally inactive precursors monoiodotyrosine and diiodotyrosine circulating in their plasma. These findings suggest that the reduced thyroid activity in infantile marasmus can be partly due to a decrease of anterior pituitary stimulation.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          21 November 2008
          : 4
          : 1
          : 43-52
          Centro de Pediatria ‘Albina R. de Patiño’, Cochabamba; Clinique universitaire de Pédiatrie, Geneva; Thyroid Research Unit, Clinique médicale universitaire, Lausanne
          178289 Horm Res 1973;4:43–52
          © 1973 S. Karger AG, Basel

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          Page count
          Pages: 10


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