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      Effect of 24,25- Dihydroxycholecalciferol on Intestinal Absorption of Calcium and Phosphate and on Parathyroid Hormone Secretion in Chronic Renal Failure

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          Abstract

          Twelve patients with chronic renal failure (CRF) requiring dialysis, 7 of whom were hypercalcaemic, were treated with 24,25-dihydroxycholecalciferol [24,25(OH)<sub>2</sub>D<sub>3</sub>; 10 μg daily for 3 months] or placebo and the treatment then crossed over for a further 3 months. Treatment with 24,25(OH)<sub>2</sub>D<sub>3</sub> was associated with small but significant increments in the fractional rates of absorption of calcium (p < 0.01) and phosphate (p < 0.05) measured by a combined radioisotope test, but even during treatment, the absorption of both calcium and phosphate remained subnormal. A significant fall in immunoreactive parathyroid hormone (i-PTH) levels occurred during treatment (p < 0.05) in the absence of significant changes in plasma ionised calcium and plasma phosphate levels. In 7 patients, treatment with 24,25(OH)<sub>2</sub>D<sub>3</sub> converted parathyroid glands which were non-suppressible by calcium infusion before treatment to suppressible ones ( > 50% suppression of i-PTH levels) at similar levels of ionised calcium. 24,25(OH)<sub>2</sub>D<sub>3</sub> may have a role in the treatment of renal osteodystrophy, especially in patients with hypercalcaemic hyperparathyroidism.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1992
          1992
          11 December 2008
          : 60
          : 3
          : 286-291
          Affiliations
          aDepartment of Nephrology and Transplantation, Royal Free Hospital, London; bRenal Unit, Lister Hospital, Stevenage, UK
          Article
          186767 Nephron 1992;60:286–291
          10.1159/000186767
          1565181
          © 1992 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 6
          Categories
          Original Paper

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