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      Acute Interstitial Nephritis due to Nicergoline (Sermion ®)

      case-report

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          Abstract

          We report a case of acute interstitial nephritis (AIN) due to nicergoline (Sermion<sup>®</sup>). A 50-year-old patient admitted to our hospital for fever and acute renal failure. Before admission, he had been taking nicergoline and bendazac lysine due to retinal vein occlusion at ophthalmologic department. Thereafter, he experienced intermittent fever and skin rash. On admission, clinical symptoms (i.e. arthralgia and fever) and laboratory findings (i.e. eosinophilia and renal failure) suggested AIN, and which was confirmed by pathologic findings on renal biopsy. A lymphocyte transformation test demonstrated a positive result against nicergoline. Treatment was consisted of withdrawal of nicergoline and intravenous methylprednisolone, and his renal function was completely recovered. To our knowledge, this is the first report of nicergoline-associated AIN.

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          Immunoallergic Granulomatous Interstitial Nephritis following Treatment with Omeprazole

          Jean-Jacques Montseny, Alain Meyrier (1998)
          A 69-year-old male who had a long history of ocular myasthenia was treated with omeprazole for 3 months. Progressive renal insufficiency was discovered fortuitously. There were no clinical or laboratory manifestations of immunoallergy. Renal biopsy revealed severe granulomatous interstitial nephritis, tubular injury and fibrosis. Histology of a liver nodule disclosed hepatic granulomatous involvement. Withdrawal of omeprazole and a short course of corticosteroids were followed by improvement but not normalization of renal function. This is the eighth report of omeprazole-induced interstitial nephritis. In the present case as in 2 others in the literature, the patients had been followed up for an autoimmune disease previously, which suggests that in patients with such a background, patients should be examined regularly for renal functional impairment during treatment with omeprazole.
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            Author and article information

            Journal
            Journal ID (publisher-id): NEF
            Journal ID (nlm-ta): Nephron
            Journal ID (doi): 10.1159/issn.1660-8151
            Title: Nephron
            Publisher: S. Karger AG
            ISSN (Print): 1660-8151
            ISSN (Electronic): 2235-3186
            Publication date Subscription-year: 2002
            Publication date (Print): September 2002
            Publication date (Electronic): 26 September 2002
            Volume: 92
            Issue: 3
            Pages: 676-679
            Affiliations
            Department of Internal Medicine and Clinical Pathology, Kangnam St. Mary’s Hospital, Catholic University of Korea, Seoul, Korea
            Article
            Publisher ID: 64096 Other ID: Nephron 2002;92:676–679
            DOI: 10.1159/000064096
            PubMed ID: 12372954
            SO-VID: 94d91b06-31ea-4af6-8c5f-099616827d6e
            Copyright © © 2002 S. Karger AG, Basel
            License:

            Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

            History
            Date received : 20 February 2002
            Page count
            Figures: 3, References: 13, Pages: 4
            Categories
            Subject: Case Report

            ScienceOpen disciplines: Cardiovascular Medicine,Nephrology
            Keywords: Acute interstitial nephritis,Nicergoline
            Data availability:
            ScienceOpen disciplines: Cardiovascular Medicine, Nephrology
            Keywords: Acute interstitial nephritis, Nicergoline

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