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      Acute Interstitial Nephritis due to Nicergoline (Sermion ®)

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          We report a case of acute interstitial nephritis (AIN) due to nicergoline (Sermion<sup>®</sup>). A 50-year-old patient admitted to our hospital for fever and acute renal failure. Before admission, he had been taking nicergoline and bendazac lysine due to retinal vein occlusion at ophthalmologic department. Thereafter, he experienced intermittent fever and skin rash. On admission, clinical symptoms (i.e. arthralgia and fever) and laboratory findings (i.e. eosinophilia and renal failure) suggested AIN, and which was confirmed by pathologic findings on renal biopsy. A lymphocyte transformation test demonstrated a positive result against nicergoline. Treatment was consisted of withdrawal of nicergoline and intravenous methylprednisolone, and his renal function was completely recovered. To our knowledge, this is the first report of nicergoline-associated AIN.

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          Immunoallergic Granulomatous Interstitial Nephritis following Treatment with Omeprazole

          A 69-year-old male who had a long history of ocular myasthenia was treated with omeprazole for 3 months. Progressive renal insufficiency was discovered fortuitously. There were no clinical or laboratory manifestations of immunoallergy. Renal biopsy revealed severe granulomatous interstitial nephritis, tubular injury and fibrosis. Histology of a liver nodule disclosed hepatic granulomatous involvement. Withdrawal of omeprazole and a short course of corticosteroids were followed by improvement but not normalization of renal function. This is the eighth report of omeprazole-induced interstitial nephritis. In the present case as in 2 others in the literature, the patients had been followed up for an autoimmune disease previously, which suggests that in patients with such a background, patients should be examined regularly for renal functional impairment during treatment with omeprazole.

            Author and article information

            S. Karger AG
            September 2002
            26 September 2002
            : 92
            : 3
            : 676-679
            Department of Internal Medicine and Clinical Pathology, Kangnam St. Mary’s Hospital, Catholic University of Korea, Seoul, Korea
            64096 Nephron 2002;92:676–679
            © 2002 S. Karger AG, Basel

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            Page count
            Figures: 3, References: 13, Pages: 4
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            Case Report

            Cardiovascular Medicine, Nephrology

            Acute interstitial nephritis, Nicergoline


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