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      Recurrence of Light Chain Nephropathy in a Renal Allograft

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          Myeloma and monoclonal gammopathies can affect the kidney in many ways with cast nephropathy and light chain deposition disease being the most commonly recognised histological entities. Renal transplantation in these patients remains controversial both because of the risk of recurrent disease affecting the graft and also because of concerns around the possibility of disease relapse within the patient. We suggest that the histological pattern of disease within the native kidneys is crucial in the overall assessment of these patients for renal transplantation. Those patients in whom renal deposition of light chains is associated with a proliferative glomerulonephritis have a considerably worse graft survival than those presenting with cast nephropathy.

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          Author and article information

          Am J Nephrol
          American Journal of Nephrology
          S. Karger AG
          June 2001
          25 June 2001
          : 21
          : 3
          : 237-240
          aManchester Institute for Nephrology and Transplantation, Manchester Royal Infirmary, Manchester; bHope Hospital, Salford, and cDepartment of Cellular Pathology, Oxford Radcliffe Hospitals, Oxford, UK
          46254 Am J Nephrol 2001;21:237–240
          © 2001 S. Karger AG, Basel

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          Figures: 1, Tables: 1, References: 14, Pages: 4
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