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Switch to Tacrolimus for Cyclosporine-Induced Gynecomastia in Liver Transplant Recipients
G. Iaria ,
L. Urbani ,
G. Catalano ,
P. De Simone ,
P. Carrai ,
S. Petruccelli ,
L. Morelli ,
L. Coletti ,
C. Garcia ,
R. Liermann ,
F. Mosca ,
F. Filipponi
July 2005
July 2005
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Abstract
We report herein on two male liver transplant (LT) recipients who presented with cyclosporine
(CsA)-related gynecomastia 6 and 10 months after transplantation. The clinical workup
showed increased luteinizing hormone (LH), associated with a slight reduction in testosterone
blood levels in one patient and increased prolactin levels in the other. After excluding
concomitant primary endocrine and/or malignant disease, conversion to tacrolimus (TAC)
was performed resulting in clinical improvement of gynecomastia and return of hormone
blood levels to normal range within 3 months. Our report confirms a putative role
of CsA in post-LT gynecomastia, reversible however upon conversion to TAC.