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      Adverse events in the treatment of multidrug-resistant tuberculosis: results from the DOTS-Plus initiative.

      The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
      Adult, Antitubercular Agents, adverse effects, Directly Observed Therapy, Estonia, Female, Humans, Latvia, Male, Medication Adherence, Peru, Philippines, Retrospective Studies, Russia, Treatment Outcome, Tuberculosis, Multidrug-Resistant, drug therapy

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          Abstract

          Adverse events associated with second-line drugs have been mentioned as obstacles in the management of multidrug-resistant tuberculosis (MDR-TB). Data on adverse events were collected from five DOTS-Plus sites in Estonia, Latvia, Peru (Lima), the Philippines (Manila) and the Russian Federation (Tomsk Oblast). The results show that among 818 patients enrolled on MDR-TB treatment only 2% of patients stopped treatment, but 30% required removal of the suspected drug(s) from the regimen due to adverse events. The study shows that adverse events are manageable in the treatment of MDR-TB in resource-limited settings provided that standard management strategies are applied.

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