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      Rating of daytime and nighttime symptoms in RLS: validation of the RLS-6 scale of restless legs syndrome/Willis-Ekbom disease.

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          Abstract

          The International Restless Legs Scale (IRLS) is the most widely used of the scales rating the severity of restless legs syndrome/Willis-Ekbom disease (RLS/WED). It has been well validated and is the primary end point for most of the therapeutic and nontherapeutic studies of RLS/WED. It has excellent psychometric properties, although it does not capture the severity of RLS under a wide variety of circumstances and times of day. Moreover, the IRLS has a large placebo effect.

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          Author and article information

          Journal
          Sleep Med.
          Sleep medicine
          Elsevier BV
          1878-5506
          1389-9457
          April 2016
          : 20
          Affiliations
          [1 ] Posthumously, Research Pharmaceutical Services, Inc., Fort Washington, PA, USA; University of Erlangen-Nuremberg, Genmany.
          [2 ] National Center of Epidemiology and CIBERNED, Carlos III Institute of Health, Madrid, Spain.
          [3 ] Somni Bene Institute for Medical Research and Sleep Medicine, Schwerin, Germany; Medical Center, University of Rostock, Rostock, Germany.
          [4 ] Department of Clinical Neurophysiology, University Medical Center, Goettingen, Germany; Paracelsus Elena Clinic, Kassel, Germany.
          [5 ] Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
          [6 ] PRA Health Sciences, Nuremberg, Germany.
          [7 ] Department of Neurology, Vanderbilt University School of Medicine, Nashville, TN, USA. Electronic address: arthur.walters@vanderbilt.edu.
          Article
          S1389-9457(15)02030-4
          10.1016/j.sleep.2015.10.014
          27318235

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