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      Mechanism of a reaction in vitro associated with delayed-type hypersensitivity.

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      Science (New York, N.Y.)
      American Association for the Advancement of Science (AAAS)

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          Abstract

          The cell type responsible for inhibition by antigen of migration in vitro of peritoneal exudate cells obtained from tuberculin-hypersensitive guinea pigs was studied. Exudate populations were separated into component cell types, the lymphocyte and the macrophage. Peritoneal lymphocytes from sensitive donors were the immunologically active cells in this system, the macrophages, being merely indicator cells which migrate. Sensitized peritoneal lymphocyte populations, upon interaction with specific antigen in vitro, elaborated into the medium a soluble material capable of inhibiting migration of normal exudate cells.

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          Author and article information

          Journal
          Science
          Science (New York, N.Y.)
          American Association for the Advancement of Science (AAAS)
          0036-8075
          0036-8075
          Jul 01 1966
          : 153
          : 3731
          Article
          10.1126/science.153.3731.80
          5938421
          953272dc-d080-4de2-984b-f22facb911d1

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