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      Can amide proton transfer-weighted imaging differentiate tumor grade and predict Ki-67 proliferation status of meningioma?

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          Abstract

          Objectives:

          To determine the utility of the amide proton transfer-weighted MR imaging in differentiating the WHO grade and predict proliferative activity of meningioma.

          Methods:

          Fifty-three patients with WHO grade I meningiomas and twenty-six patients with WHO grade II meningiomas underwent conventional and APT-weighted sequences on a 3.0 Tesla MR before clinical intervention. The APT-weighted (APTw) parameters in the solid tumor region were obtained and compared between two grades using the t-test, the receiver operating characteristic (ROC) curve was used to assess the best parameter for predicting the grade of meningiomas. Pearson’s correlation coefficient was calculated between the APTw max and Ki-67 labeling index in meningiomas.

          Results:

          The APTw max and APTw mean values were not significantly different between WHO grade I and grade II meningiomas ( P=0.103 and P=0.318). The APTw min value was higher and the APTw max-mim value was lower in WHO grade II meningiomas than in WHO grade I tumors. ( P=0.027 and P=0.019). But the APTw min was higher and the APTw max-min was lower in microcystic meningiomas than in WHO grade II meningiomas( P= 0.001 and P=0.006). The APTw min combined with APTw max-min showed the best diagnostic performance in predicting the grade of meningiomas with an AUC of 0.772. The APTw max value was positively correlated with Ki-67 labeling index (r=0.817, P<0.00l) in meningiomas, the regression equation for the Ki-67 labeling index (%) (Y) and APTw max (%)(X) was Y=4.9×X-12.4 (R 2 =0.667, P< 0.001).

          Conclusion:

          As a noninvasive imaging method, the ability of APTw-MR imaging in differentiating the grade of meningiomas is limited, but the technology can be used to predict the proliferative activity of meningioma.

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          Author and article information

          Journal
          9114774
          20371
          Eur Radiol
          Eur Radiol
          European radiology
          0938-7994
          1432-1084
          20 March 2019
          18 March 2019
          October 2019
          01 October 2020
          : 29
          : 10
          : 5298-5306
          Affiliations
          [1. ]Department of Radiology, Affiliated Hospital of Jining Medical University, Jining Medical University, Guhuai Road No.89, Rencheng District, Jining, Shandong, 272029
          [2. ]Department of Radiology, Zhujiang Hospital, Southern Medical University, Gongye Road M No.253, Haizhu District, Guangzhou, Guangdong, 510282
          [3. ]Department of Neurology, Zhujiang Hospital, Southern Medical University, Gongye Road M No.253, Haizhu District, Guangzhou, Guangdong, 510282, China.
          [4. ]Department of Clinical Laboratory, Jining NO. 1 People’s Hospital, 6 Jiankang Road, Jining, 272011, China.
          [5. ]Department of Radiology, Weihai Municipal Hospital, Heping Road M No.70, Weihai, Shandong, 264200, China.
          [6. ]Division of MR Research, Department of Radiology, Johns Hopkins University School of Medicine, 600N. Wolfe Street, Park 336, Baltimore, Maryland 21287, USA
          Author notes
          [#]

          These authors have contributed equally to this work.

          [* ]Corresponding author: Please address correspondence to Zhibo Wen, MD. Professor Department of Radiology, Zhujiang Hospital, Southern Medical University, Gongye Road M No.253, Haizhu District, Guangzhou, Guangdong, 510282, China. Phone: +86-13802914951; 86-20-61643461., zhibowen@ 123456163.com
          Article
          PMC6717551 PMC6717551 6717551 nihpa1524269
          10.1007/s00330-019-06115-w
          6717551
          30887206
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