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      DNA Release and Appearance of Antinuclear Antibodies in Chronic Hemodialysis Patients

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          The presence of free serum DNA and/or antibodies against nuclear antigens was studied in 65 patients in chronic hemodialysis. Most of patients showed increased levels of both free single-stranded DNA (ss DNA) (28 out of 29) and native (double-stranded) DNA (n DNA) (25 out of 28) at the beginning of each dialysis session (69 ± 26 vs. 119 ± 15, p < 0.05) suggesting a rapid in vivo degradation of the n DNA released. 15 out of 65 patients (23%) developed low anti-ss DNA antibody titers by Millipore filtration assay. 2 of them presented anti-n DNA antibodies simultaneously. Isolated anti-n DNA, anti-Sm and anti-RNP antibodies were systematically negative in all patients. No relationship was found between the presence of anti-ss DNA antibodies and the type of nephropathy, the duration of treatment and the method of dialysis. The fate of a renal allograft was studied in 12 patients after having measured serum-free DNA and anti-DNA antibodies. The 4 patients with good graft function after 2 years of transplantation had significantly higher circulating ss-DNA levels than the other 8 patients whose grafts were rejected.

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          Author and article information

          S. Karger AG
          03 December 2008
          : 31
          : 2
          : 164-169
          aRenal Division, Fundación Jiménez Díaz and bMicrobiology Department, Hospital Clinico, Madrid, Spain
          182637 Nephron 1982;31:164–169
          © 1982 S. Karger AG, Basel

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          Page count
          Pages: 6
          Original Paper

          Cardiovascular Medicine, Nephrology

          Hemodialysis, DNA, Anti-DNA antibodies, Renal transplantation


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