• Record: found
  • Abstract: found
  • Article: not found

Multilineage potential of adult human mesenchymal stem cells.

Science (New York, N.Y.)

Adipocytes, cytology, Adult, Apoptosis, Bone Marrow Cells, Cell Differentiation, Cell Division, Cell Lineage, Cell Separation, Cells, Cultured, Chondrocytes, Fibroblasts, Flow Cytometry, Humans, Mesoderm, Middle Aged, Osteocytes, Phenotype, Stem Cells

Read this article at

      There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.


      Human mesenchymal stem cells are thought to be multipotent cells, which are present in adult marrow, that can replicate as undifferentiated cells and that have the potential to differentiate to lineages of mesenchymal tissues, including bone, cartilage, fat, tendon, muscle, and marrow stroma. Cells that have the characteristics of human mesenchymal stem cells were isolated from marrow aspirates of volunteer donors. These cells displayed a stable phenotype and remained as a monolayer in vitro. These adult stem cells could be induced to differentiate exclusively into the adipocytic, chondrocytic, or osteocytic lineages. Individual stem cells were identified that, when expanded to colonies, retained their multilineage potential.

      Related collections

      Author and article information



      Comment on this article