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      The Role of the Kidney in the Metabolism of Plasma Proteins

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          Abstract

          The role of the kidney in the metabolism of plasma proteins can be defined by metabolic turnover techniques using representative radioiodinated, purified proteins. Low molecular weight (MW) proteins ( < 50,000 MW) readily transverse the glomerular filter and are largely taken up and catabolized by tubular cells; for this class of proteins the kidney is a primary organ of catabolism. Intermediate and high M W proteins ( > 60,000 M W) are generally retained by the glomerular filter and, therefore, do not normally have a significant exposure to tubular catabolic sites; for this class of proteins the kidney is not normally a primary organ of catabolism. Intermediate and even high M W proteins do pass through an abnormal glomerular filter, and are thereby lost to the body as intact proteins or are taken up and catabolized within tubular cells. In tubular diseases low MW proteins enter the tubular lumen in normal fashion, but are not taken up and catabolized within tubular cells. Thus, their loss pathway changes reciprocably from one of endogenous catabolism to excretion; this is the origin of tubular proteinuria. In nephron-loss disease, both excretion and endogenous catabolism of low MW proteins are diminished. Thus, these proteins accumulate in the blood.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          978-3-8055-2597-8
          978-3-318-02024-3
          1660-8151
          2235-3186
          1974
          1974
          28 November 2008
          : 13
          : 1
          : 35-66
          Affiliations
          Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, Md.
          Article
          180368 Nephron 1974;13:35–66
          10.1159/000180368
          4607245
          © 1974 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 32
          Categories
          Symposium on Proteinuria

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