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      c- fos Expression in Vasopressin and Oxytocin Neurons Reveals Functional Heterogeneity within Magnocellular Neurons

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          The c- fos protein is rapidly induced in hypothalamic magnocellular nuclei following hemorrhage. We used specific antibodies directed against c- fos and either vasopressin (AVP) or oxytocin (OT) neurophysin to investigate c- fos activation in individual AVP and OT neurons. AVP and OT neurons expressed c- fos in response to hypovolemic stimuli. Following a protocol of incremental hemorrhage, AVP and OT neurons expressed c- fos with a graded response that correlated with stimulus intensity. As the volume of hemorrhage increased, there was an increase in the number of cells expressing c- fos as well as in the amount of c- fos immunoreactivity per cell. These increases correlated with the amount of hormone released into the peripheral blood. In addition, a differential pattern of activation for AVP neurons occurred in response to hemorrhagic stimuli. AVP neurons in the supraoptic nucleus (SON) had a lower threshold for response than those in the paraventricular nucleus (PVN). For OT, activation required a greater blood loss than AVP and c- fos expression encompassed both SON and PVN neurons. We conclude that c- fos expression is proportional to stimulus intensity and reveals functional heterogeneity among magnocellular neurons.

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          Author and article information

          S. Karger AG
          08 April 2008
          : 57
          : 3
          : 388-400
          Departments of Medicine and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, Pa., Endocrine Division, Children’s Hospital, Boston, Mass., USA
          126384 Neuroendocrinology 1993;57:388–400
          © 1992 S. Karger AG, Basel

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          Pages: 13
          Original Paper


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