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      Sivelestat sodium and mortality in pneumonia patients requiring mechanical ventilation: propensity score analysis of a Japanese nationwide database.

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          Abstract

          Sivelestat is widely used in Japan for the treatment of acute respiratory distress syndrome caused by pneumonia. Although the efficacy of sivelestat was reported in several Japanese studies in the early 2000 s, a multinational randomized control trial did not support these findings. We therefore conducted the present study to examine the association between the use of sivelestat and mortality in pneumonia patients requiring mechanical ventilation.

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          Author and article information

          Journal
          J Anesth
          Journal of anesthesia
          Springer Nature
          1438-8359
          0913-8668
          Jun 2017
          : 31
          : 3
          Affiliations
          [1 ] Department of Public Health, Health Management and Policy, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-0813, Japan. miwakishimoto@gmail.com.
          [2 ] Department of Anesthesiology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-0813, Japan. miwakishimoto@gmail.com.
          [3 ] Department of Clinical Epidemiology and Health Economics, School of Public Health, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
          [4 ] Department of Anesthesiology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-0813, Japan.
          [5 ] Department of Public Health, Health Management and Policy, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-0813, Japan.
          Article
          10.1007/s00540-017-2327-1
          10.1007/s00540-017-2327-1
          28243749

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