Blog
About

12
views
0
recommends
+1 Recommend
1 collections
    1
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      BONE MINERAL STATUS AND METABOLISM DISORDERS IN PATIENTS WITH CHRONIC SPINAL CORD INJURY

      Read this article at

      ScienceOpenPublisher
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Background. The study of late complications, including osteoporosis, is urgent due to the increasing life expectancy of patients with complete spinal cord injury (SCI). Objective. The aim of the study is to evaluate bone mineral status and bone turnover markers in the patients with chronic SCI. Methods. 73 SCI patients and 57 healthy persons were examined. Bone status was determined by ultrasound (US) densitometry. Bone turnover markers and vitamin D were evaluated by electrochemiluminescence method. Results. In the SCI patients bone mineral status was significantly lower compared with the individuals of control group. The stiffness index (SI) was 51.4±11.8 % vs. 98.5±16.6 %, p<0.05 in men and 50.1±9.8 % vs. 92.9±11.1 %, p<0.05 in women. In the SCI patients the levels of bone turnover markers were significantly higher than the reference values. The bone mineral status of patients with SCI, which occurred before peak bone mass development, is significantly worse, compared with the individuals with the already developed peak bone mass, that makes them a high risk group for fracture. Conclusions. SCI leads to increased bone resorption with development of secondary osteoporosis (according to the ultrasound densitometry of calcaneal bone). In chronic SCI, bone resorption is higher than in the individuals with combined low levels of vitamin D, and the absence of axial load results in continued loss of bone mass.

          Related collections

          Author and article information

          Journal
          International Journal of Medicine and Medical Research
          Ukrmedknyha
          01 July 2018
          : 0
          : 1
          Affiliations
          [1 ] SI “D. F. Chebotariov Institute of Gerontology, NAMS of Ukraine”
          Article
          6b2ed4fffb1e4f628a344cd03cd8e7be
          10.11603/ijmmr.2413-6077.2018.1.8701

          This work is licensed under a Creative Commons Attribution 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

          Categories
          Medicine
          R

          Comments

          Comment on this article