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      Matrigel: basement membrane matrix with biological activity.

      1 ,
      Seminars in cancer biology
      Elsevier BV

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          Abstract

          The basement membrane extracellular matrix contacts epithelial, endothelial, fat and smooth muscle cells. Because this extracellular matrix is so thin, it had been hard to study its composition, structure, and function. An extract of a tumor was found to contain all of the components present in basement and to be very biologically active. This extract, termed Matrigel, Cultrex, or EHS matrix, promotes cell differentiation, and is used to measure the invasive activity of tumor cells. In vivo, it is used for measuring angiogenic inhibitors and stimulators, to improve graft survival, repair damaged tissues, and increase tumor growth.

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          Author and article information

          Journal
          Semin Cancer Biol
          Seminars in cancer biology
          Elsevier BV
          1044-579X
          1044-579X
          Oct 2005
          : 15
          : 5
          Affiliations
          [1 ] NIH, NIDCR, 30/433, 30 Convent Dr. MSC 4370, Bethesda, MD 20892-4370, USA. hkleinman@dir.nidcr.nih.gov
          Article
          S1044-579X(05)00031-3
          10.1016/j.semcancer.2005.05.004
          15975825
          95b9eb84-313f-4cf5-8add-6e85a1a5a5dd
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