9
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: not found
      • Article: not found

      Novel solid forms of the anti-tuberculosis drug, Isoniazid: ternary and polymorphic cocrystals

      , , ,
      CrystEngComm
      Royal Society of Chemistry (RSC)

      Read this article at

      ScienceOpenPublisher
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Related collections

          Most cited references40

          • Record: found
          • Abstract: not found
          • Article: not found

          Solubility Advantage of Amorphous Drugs and Pharmaceutical Cocrystals

            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Crystal engineering of the composition of pharmaceutical phases. Do pharmaceutical co-crystals represent a new path to improved medicines?

            The evolution of crystal engineering into a form of supramolecular synthesis is discussed in the context of problems and opportunities in the pharmaceutical industry. Specifically, it has become clear that a wide array of multiple component pharmaceutical phases, so called pharmaceutical co-crystals, can be rationally designed using crystal engineering, and the strategy affords new intellectual property and enhanced properties for pharmaceutical substances.
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              The salt-cocrystal continuum: the influence of crystal structure on ionization state.

              Salts and cocrystals are multicomponent crystals that can be distinguished by the location of the proton between an acid and a base. At the salt end of the spectrum proton transfer is complete, and on the opposite end proton transfer is absent in cocrystals. However, for acid-base complexes with similar pK(a) values, the extent of proton transfer in the solid state is not predictable and a continuum exists between the two extremes. For these systems, both the DeltapK(a) value (pK(a) of base - pK(a) of acid) and the crystalline environment determine the extent of proton transfer. A total of 20 complexes containing theophylline and guest molecules with DeltapK(a) values less than 3 have been prepared, resulting in 13 cocrystals, five salts, and two complexes with mixed ionization states based on IR spectroscopy and single-crystal diffraction data. We propose modifications to the DeltapK(a) rule for selecting salt screen counterions that focus on the discovery of solid forms with useful physical properties rather than an arbitrary cutoff value for DeltapK(a).
                Bookmark

                Author and article information

                Journal
                CRECF4
                CrystEngComm
                CrystEngComm
                Royal Society of Chemistry (RSC)
                1466-8033
                2013
                2013
                : 15
                : 29
                : 5877
                Article
                10.1039/c3ce40729b
                95c1deaf-28a5-40f2-9a96-4a250b823c92
                © 2013
                History

                Comments

                Comment on this article