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      Gene activation and protein expression following ischaemic stroke: strategies towards neuroprotection

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          Abstract

          Current understanding of the patho‐physiological events that follow acute ischaemic stroke suggests that treatment regimens could be improved by manipulation of gene transcription and protein activation, especially in the penumbra region adjacent to the infarct. An immediate reduction in excitotoxicity in response to hypoxia, as well as the subsequent inflammatory response, and beneficial control of reperfusion via collateral revascularization near the ischaemic border, together with greater control over apoptotic cell death, could improve neuronal survival and ultimately patient recovery. Highly significant differences in gene activation between animal models for stroke by middle cerebral artery occlusion, and stroke in patients, may explain why current treatment strategies based on animal models of stroke often fail. We have highlighted the complexities of cellular regulation and demonstrated a requirement for detailed studies examining cell specific protective mechanisms after stroke in humans.

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          Author and article information

          Journal
          J Cell Mol Med
          J. Cell. Mol. Med
          10.1111/(ISSN)1582-4934
          JCMM
          Journal of Cellular and Molecular Medicine
          Blackwell Publishing Ltd (Oxford, UK )
          1582-1838
          1582-4934
          01 May 2007
          January 2005
          : 9
          : 1 ( doiID: 10.1111/jcmm.2005.9.issue-1 )
          : 85-102
          Affiliations
          [ 1 ]Biological Sciences Department, Manchester Metropolitan University, Chester St, Manchester, UK
          [ 2 ]Servicio de Neurologia, Hospital Universitari de Bellvitge, Hospitalet de Llobregat, Barcelona, Spain.
          [ 3 ]Department of Pathology, Stopford Building, Manchester University, Manchester, UK
          Author notes
          *Correspondence to: Shant KUMAR, University of Manchester, Laboratory Medicine Academic Group, Stopford Building, Oxford Road, Manchester M13 9PT, UK. Tel.: +44 (0)161 275 5298, Fax: +44 (0)161 275 5289 E‐mail: Shant.Kumar@ 123456man.ac.uk
          Article
          PMC6741338 PMC6741338 6741338 JCMM85
          10.1111/j.1582-4934.2005.tb00339.x
          6741338
          15784167
          Page count
          References: 105, Pages: 18
          Categories
          Neuroscience Review Series
          Custom metadata
          2.0
          January 2005
          Converter:WILEY_ML3GV2_TO_NLMPMC version:5.6.9 mode:remove_FC converted:12.09.2019

          angiogenesis, gene expression, stroke

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