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      Vascular endothelium – Gatekeeper of vessel health

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          Abstract

          The vascular endothelium is an interface between the blood stream and the vessel wall. Changes in this single cell layer of the artery wall are believed of primary importance in the pathogenesis of vascular disease/atherosclerosis. The endothelium responds to humoral, neural and especially hemodynamic stimuli and regulates platelet function, inflammatory responses, vascular smooth muscle cell growth and migration, in addition to modulating vascular tone by synthesizing and releasing vasoactive substances. Compromised endothelial function contributes to the pathogenesis of cardiovascular disease; endothelial ‘dysfunction’ is associated with risk factors, correlates with disease progression, and predicts cardiovascular events. Therapies for atherosclerosis have been developed, therefore, that are directed towards improving endothelial function.

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          Author and article information

          Journal
          0242543
          890
          Atherosclerosis
          Atherosclerosis
          Atherosclerosis
          0021-9150
          1879-1484
          14 April 2019
          09 March 2016
          May 2016
          23 April 2019
          : 248
          : 97-109
          Affiliations
          [a ]Vascular Biology and Therapeutics Laboratory, Dublin City University, Dublin, Ireland
          [b ]Department of Surgery, University of Rochester Medical Center, Rochester, NY, USA
          Author notes
          [* ]Corresponding author. University of Rochester Medical Center, Department of Surgery, Box SURG, 601 Elmwood Avenue, Rochester, NY, 14642-8410, USA. Eileen_Redmond@ 123456urmc.rochester.edu (E.M. Redmond).
          Article
          PMC6478391 PMC6478391 6478391 nihpa1022957
          10.1016/j.atherosclerosis.2016.03.007
          6478391
          26994427
          95e30e49-7b46-41f4-9471-1cd9289678dc
          History
          Categories
          Article

          Clinical therapies,Endothelial dysfunction,Atherosclerosis,Endothelium,Review,Vessel remodeling,Cardiovascular disease

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