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      Using solution X-ray scattering to determine the high-resolution structure and morphology of PEGylated liposomal doxorubicin nanodrugs.

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          Abstract

          Among nanodrugs, PEGylated nanoliposomes loaded with an active agent are of major importance. In this paper we studied the structures and morphology of PEGylated nanoliposomes before and after remote loading with doxorubicin.

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          Author and article information

          Journal
          Biochim. Biophys. Acta
          Biochimica et biophysica acta
          Elsevier BV
          0006-3002
          0006-3002
          Jan 2016
          : 1860
          : 1 Pt A
          Affiliations
          [1 ] Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel; The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.
          [2 ] Laboratory of Membrane and Liposome Research, IMRIC, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel; The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.
          [3 ] Laboratory of Membrane and Liposome Research, IMRIC, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel.
          [4 ] Laboratory of Membrane and Liposome Research, IMRIC, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel; The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel. Electronic address: chezyb@gmail.com.
          [5 ] Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel; The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel. Electronic address: uri.raviv@mail.huji.ac.il.
          Article
          S0304-4165(15)00244-5
          10.1016/j.bbagen.2015.09.012
          26391840
          95e3314a-9e82-4250-9937-0a8b0d33dcd5
          History

          WAXS,Drug delivery,Generic drugs,Liposomal doxorubicin,PEGylated liposomes,SAXS

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