There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
The ability to resist the urge to eat requires the proper functioning of neuronal
circuits involved in top-down control to oppose the conditioned responses that predict
reward from eating the food and the desire to eat the food. Imaging studies show that
obese subjects might have impairments in dopaminergic pathways that regulate neuronal
systems associated with reward sensitivity, conditioning and control. It is known
that the neuropeptides that regulate energy balance (homeostatic processes) through
the hypothalamus also modulate the activity of dopamine cells and their projections
into regions involved in the rewarding processes underlying food intake. It is postulated
that this could also be a mechanism by which overeating and the resultant resistance
to homoeostatic signals impairs the function of circuits involved in reward sensitivity,
conditioning and cognitive control.
Published by Elsevier Ltd.